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Scleroderma
Published in Charles Theisler, Adjuvant Medical Care, 2023
Scleroderma is a chronic autoimmune disease with two main types. (1) Localized scleroderma has two subtypes and only affects the skin. It often appears as thick, hard waxy patches (morphea type) or streaks (linear type) on the skin. Symptoms tend to come and go with flare-ups and periods of relatively stability. It is not uncommon for the condition to go away or to stop progressing without treatment.1 Tightening of the skin can cause fingers to curl and lose their mobility. (2) Systemic scleroderma has three subtypes and can result in changes in the skin and muscles, circulation of blood, and extend to internal organs, especially the kidneys, lungs, heart, or digestive tract.
Inflammatory, Hypersensitivity and Immune Lung Diseases, including Parasitic Diseases.
Published in Fred W Wright, Radiology of the Chest and Related Conditions, 2022
There are two broad forms of scleroderma based on clinical findings: (i) a limited form and (ii) a diffuse form. About 60% of patients have limited disease usually manifested by the 'CREST' syndrome - which is an Americanism of the initial letters of: 'calcinosis of skin, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly and telangectasia'.
The Musculoskeletal System and Its Disorders
Published in Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss, Understanding Medical Terms, 2020
Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss
Scleroderma is often diagnosed by what is called the CREST syndrome, the presence of calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia. Since there is no specific treatment, general supportive therapy is indicated.
Identifying barriers and facilitators to physical activity for people with scleroderma: a nominal group technique study
Published in Disability and Rehabilitation, 2021
Sami Harb, Julie Cumin, Danielle B. Rice, Sandra Peláez, Marie Hudson, Susan J. Bartlett, Alexandra Roren, Daniel E. Furst, Tracy M. Frech, Christelle Nguyen, Warren R. Nielson, Brett D. Thombs, Ian Shrier
Participants’ sociodemographic characteristics were generally similar to those of participants in the SPIN Cohort [23,24]. There was less than a 5% difference between our sample and the SPIN Cohort with respect to sex, race, and marital status categories. The mean age was approximately the same, and both mean years of educational attainment and years since scleroderma diagnosis were within two years. They differed on full- or part-time employment (29% of participants versus 41% of cohort) and diffuse scleroderma subtype (59% of participants versus 41% of cohort). Approximately half of SPIN Cohort patients are completely inactive, and most of the active patients engage in low intensity activities such as walking [9]. Although there was only one completely inactive patient in the present study, there were 8 patient examples of barriers (across 4 nominal group technique sessions) related to non-adherence to physical activity, including hopelessness due to physical limitations, depression, motivation when not feeling well, and fluctuations in health making it difficult to keep a consistent routine.
Association between Skin Thickness Measurements with Corneal Biomechanical Properties and Dry Eye Tests in Systemic Sclerosis
Published in Ocular Immunology and Inflammation, 2019
Ziya Ayhan, Mahmut Kaya, Taylan Ozturk, Gul Arikan, Merih Birlik
Scleroderma is an autoimmune progressive chronic disorder of unknown aetiology; it is characterised by tightening and thickening of the skin associated with widespread microangiopathy and multi-organ fibrosis.1–3 It can be classified as limited cutaneous scleroderma (lcSSc) or diffuse cutaneous scleroderma (dcSSc) according to extent of skin involvement shown to influence the patient’s daily functions and survival.4,5 In lcSSc, the fibrosis is mainly restricted to the hands, arms and face, and Raynaud’s phenomenon is present for several years before fibrosis appears; pulmonary hypertension is frequent, and anti-centromere antibodies occur in 50–90% of those patients. Diffuse cutaneous scleroderma is a rapidly progressing disorder that affects large areas of the skin and compromises internal organs. Progressive fibrosis in the skin and lungs accounts for the significant morbidity and mortality of patients with SSc.6
“I'm still dad”: The Impact of Scleroderma on being a Father
Published in Occupational Therapy In Health Care, 2018
Janet L. Poole, Donna Haygood, Cindy Mendelson
Scleroderma is an autoimmune collagen disease that is manifested by hardening and fibrosis of the skin and internal organs. While the prevalence is 4.6 times greater in females than males (Meier et al., 2012), the disease is more severe in men resulting in a poorer prognosis and increased occurrence of lung and heart involvement (Elhai et al., 2016). The mean age of onset, between 30–50 years of age, is during the peak years when males are becoming or being fathers. Systemic scleroderma has two main subtypes: limited cutaneous scleroderma and diffuse cutaneous scleroderma. Limited systemic scleroderma (lSSc) has fibrotic skin involvement limited to the hands, fingers and face and later involvement of the internal organs (Connolly & Tuffanelli, 2004). In diffuse systemic scleroderma (dSSc), the more severe subtype, skin involvement occurs more proximally with early internal organ involvement.