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Benign Neoplasms
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Abdullah Demirbaş, Ömer Faruk Elmas, Necmettin Akdeniz
Differential diagnosis: A tumor, skin metastasis, calcinosis cutis, and foreign body granuloma can be considered. If multiple infundibular cysts are present, the possibility of relevant syndromes should be investigated in the right clinical context, including Gardner’s syndrome, Gorlin’s syndrome, and pachyonychia congenita type 2.
Dermal filler complications and management
Published in Michael Parker, Charlie James, Fundamentals for Cosmetic Practice, 2022
As in the treatment of inflammatory delayed onset nodules, the management of a foreign body granuloma should only be managed by an experienced practitioner who is appropriately trained in the conservative and surgical management of these nodules. Initial therapy is recommended as intralesional steroid injection. Concomitant hyaluronidase therapy may also be useful in dissolving the granulomatous component. Should conservative management fail, the next step is surgical excision of the foreign body and its surrounding granulomatous capsule. If the patient still wants further treatment then this should only be performed in an operating theatre by an experienced doctor or surgeon due to the risk of post-operative infection and scar formation.
Breast
Published in Joseph Kovi, Hung Dinh Duong, Frozen Section In Surgical Pathology: An Atlas, 2019
Joseph Kovi, M.D. Hung Dinh Duong
Chronic abscess should be differentiated from “inflammatory” carcinoma, and from foreign body granuloma. In “inflammatory” carcinoma, the dilated dermal lymphatics of the breast are filled with large, anaplastic carcinoma cells. The presence of foreign material is the hallmark of foreign body granuloma (Figure 27).
“New classification of late and delayed complications after dermal filler: Localized or Generalized?”
Published in Journal of Cosmetic and Laser Therapy, 2020
Hwa Jung Ryu, Bo Young Kim, Sook In Ryu, Na Young Kim, Joo Yeon Ko, Young Suck Ro, Il-Hwan Kim, Jeong Eun Kim
Therefore, we propose a new classification method for delayed complications after injection with dermal fillers: Localized and Generalized (Table 2). We defined Localized complications as cases where symptoms appeared in areas with defined boundaries. Clinically, all patients classified to type I showed inflammatory nodules. Regarding the inflammatory reactions revealed foreign body granuloma on histologic findings, Localized type was confined to the filler injection sites and had tendencies to show erythematous nodules. Generalized complications were defined as erythematous swollen patches on the entire face where boundaries could not be defined, with multiple inflammatory nodules in the filler injection sites, as well as filler migration to distant sites. The advantages of this classification are that this classification includes most patients with filler complications and it is simple and classifies patients based on their symptoms and physical examination without further evaluation, such as biopsy or microbial examination. This simple classification system can also be used to predict the prognosis of patients with complications. In the Generalized complications group, systemic symptoms, including fever, myalgia, and chills were more common and the treatment response was poor. In addition, fewer patients with Generalized complications showed complete remission than those with Localized complications. This new classification is indeed applicable and simple and is expected to predict effective treatment and prognosis.
Granuloma as a complication of polycaprolactone-based dermal filler injection: ultrasound and histopathology studies
Published in Journal of Cosmetic and Laser Therapy, 2019
Ewa Skrzypek, Barbara Górnicka, Daisy Miriam Skrzypek, Mlosek Robert Krzysztof
The nodules were firm, movable and not painful upon palpation. The HFU showed the hypoechogeneous lesion, with irregular borders, sized 0.378 cm × 0.416 cm, located within the subcutaneous tissue, approx. 0.5 mm below dermis (Figure 1). Microbial studies showed numerous colonies of Streptococus parasanguinis. Histopathology analysis showed numerous round cavities within the giant cell cytoplasm or adjacent to giant cells containing asteroid bodies. Numerous giant cells were diffused on the matrix of fibrous connective tissue accompanied by macrophage and lymphocyte infiltration (Figure 2). Immunohistochemistry analysis using the anti-CD68 antibody confirmed the presence of numerous macrophages and CD68-positive polynuclear giant cells (Figure 3). The histopathological diagnosis was foreign body granuloma. The patient was offered intralesional injections of triamcinolone (1 mg/mL) and 5-fluorouracyl (5FU) (50 mg/mL). The patient refused her consent to treatment. Having withdrawn her consent, the patient did not attend any more appointment and was, therefore, lost to follow up.
Sharp foreign body ingestion by a young girl
Published in Alexandria Journal of Medicine, 2018
Sometimes objects remain in the GIT for many years.6 Henderson and Gaston reported nine incidences of perforation in 800 cases of foreign body ingestion at Boston City hospital, perforation occurred without signs of peritonitis; they observed two asymptomatic patients with straight pins lodged in their spleens.6 Sharp pointed objects such as sewing needles may penetrate the bowel wall. If abdominal pain, tenderness, fever or leukocytosis occur, immediate surgical removal of the offending object is indicated. Abscess or foreign body granuloma (type IV hypersensitivity reaction – delayed type of cell mediated immunity) formation are the usual outcome without surgical therapy.7 In our case one of the needles evidently had perforated the ascending colon and lodged in a foreign body granuloma in the retrocolic area while the other perforated the stomach and was lodged in the left lobe of the liver. Abel et al. reported a similar case of a pin in the left lobe of the liver, but the patient was much younger (11 months old).8