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Primary localized cutaneous amyloidosis
Published in Dimitris Rigopoulos, Alexander C. Katoulis, Hyperpigmentation, 2017
Large masses of amyloid are found in the dermis and subcutis with prominent deposition around adnexal structures and blood vessels. There is usually a marked infiltrate of plasma cells, some of them with large Russel bodies. Foreign body giant cells and focal classification may be seen. Deposits do not stain with antikeratin antibodies.
Nail changes in systemic diseases and drug reactions
Published in Eckart Haneke, Histopathology of the NailOnychopathology, 2017
In the dermis and subcutis, nodules with one or more areas of central fibrinoid collagen degeneration being homogenously eosinophilic are found. Both nuclear fragments and basophilic material may be present. Around the degenerative foci, palisading histiocytes are seen. Foreign body giant cells are often present. Proliferating blood vessels are found in the surrounding fibrosis. The inflammatory infiltrate is sparse to moderate with lymphocytes and neutrophils predominating. Perforation with transepidermal elimination of the degenerated fibrinoid material may occur.136
Differential diagnoses of psoriasis
Published in M. Alan Menter, Caitriona Ryan, Psoriasis, 2017
Rosacea is a chronic inflammatory disorder of the facial skin characterized by transient or persistent facial flushing, erythema, telangetasia, and often papules and pustules, typically involving the central face (nose, forehead, cheeks, and chin).99 Subtypes of rosacea include erythematotelangiectatic rosacea, papulopustular rosacea, phymatous rosacea, and ocular rosacea.99 Rosacea is a common disease, considered more common in fair-skinned individuals.100 Women are more affected than men. It is most common from 30 to 50 years of age, but can be seen in all ages.100 The development of rhinophyma is more common in men.100 Etiology remains unknown. Patients often report burning and erythema is triggered by irritants such as heat, sun exposure, alcohol, emotion, stress, hot drinks, and spicy food.99,100 Histopathology shows dilated superficial capillaries, solar elastosis with variable inflammation from mild perivascular lymphohistiocytic infiltrate to perifollicular, and perivascular infiltrate in papular rosacea.100,101 Foreign-body giant cells may be observed.100,102 Some lesions can contain granulomas which can be epitheliod, elastolytic, or palisaded around altered collagen.100–102 Demodex folliculorum is often observed.100
Neuropathology Evaluation of in Utero Correction of Myelomeningocele and Complications of Late-Onset GBS Infection
Published in Fetal and Pediatric Pathology, 2023
Sarah Edminster, Tai-Wei Wu, Alexander Van Speybroeck, Jason Chu, Denise A. Lapa, Ramen H. Chmait, Linda J. Szymanski
The dural patch used in this case was comprised of Type III/I collagen of fetal bovine origin (Durepair patch 62100). The response of the surrounding tissues, including the neural placode (Fig. 4a,b), appeared to be like that seen in the fetal sheep model with the use of HADM, in that it allowed for vascularization and ingrowth of cells from the dermis and neural cells into the patch, thus intertwining the three of them (Fig. 4c,d) [4]. Also seen in this case was infiltrating inflammation from the host tissue and GBS within the patch. With the co-existent leptomeningitis, it is difficult to ascertain whether all the pathologic changes noted were due to the dural patch alone or secondary to the infection. Finally, there was a limited foreign body giant cell response around the patch, extensive leptomeningeal fibrosis, and subcutaneous scar tissue secondary to surgical intervention. Currently, the performance of these dural patches and their pathology in humans remains limited primarily to studies in animal models.
Pain, osteolysis, and periosteal reaction are associated with the STRYDE limb lengthening nail: a nationwide cross-sectional study
Published in Acta Orthopaedica, 2021
Jan Duedal Rölfing, Søren Kold, Tobias Nygaard, Mindaugas Mikuzis, Michael Brix, Christian Faergemann, Martin Gottliebsen, Michael Davidsen, Juozas Petruskevicius, Ulrik Kähler Olesen
Figure 2 highlights the time-dependency of the observed adverse event with neither sign of osteolysis nor periosteal reaction 11 weeks before the fulminant appearance. Figure 2 also demonstrates that the radiographic signs can mimic infection or tumor. Cortical destruction and marked periosteal reaction, as well as soft-tissue involvement and swelling, are evident on the postoperative MRI findings of the right compared with the asymptomatic left tibia of the same patient, who had both Stryde nails (right side with discoloration, left side without discoloration) removed simultaneously. Importantly, none of the obtained biopsies were culture-positive. However, a biopsy from the medullary cavity revealed an inflammatory reaction (acute/chronic) with foreign-body giant cells and metallic material. Similar findings were made in patient no. 17 (Supplementary data).
Rotator cuff repair with biological graft augmentation causes adverse tissue outcomes
Published in Acta Orthopaedica, 2020
Mustafa S Rashid, Richard D J Smith, Navraj Nagra, Kim Wheway, Bridget Watkins, Sarah Snelling, Stephanie G Dakin, Andrew J Carr
Histology using H&E staining demonstrated significant disruption, on qualitative review, of the extracellular matrix (ECM) in the patch augmentation groups compared with the control group (Figure 2A–C). Specifically, sections demonstrated reduced crimp pattern, increased friability of the matrix, and lack of parallel oriented collagen fibers. Sections from the control group (conventional repair without patch augmentation) resembled a similar appearance to normal tendon. Permacol sections had more disruption of the ECM than GraftJacket sections on qualitative assessment. Results for total cell count, foreign-body giant cell count, and vascularity grading are presented in Figure 2. There was generally no significant difference between the groups; however, the tissue sections of one patient in Group 2 (Permacol patch) had a distinctly different histological appearance (Figure 2D). These sections showed markedly increased cellularity. Morphological features of cells suggest they are not tendon fibroblasts, as was seen in other patients’ tissue sections, but rather a dense infiltration of immune cells. Clinically, this patient complained of a painful arthrofibrosis 1-week post-surgery, which settled with analgesia from the general practitioner. The serum C-reactive protein level at 4 weeks was 10 mg/dL.