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Photothermal Lasers
Published in Anita Prasad, Laser Techniques in Ophthalmology, 2022
PRP can be used alone or in conjunction with medical therapy or surgical interventions. Retinal ischaemia provides the neovascular drive, and PRP involves treating large portions of ischaemic retina, with photothermal laser, to reduce hypoxia, reverse ischaemic drive, and stabilize the vascular condition.
Platelet-Rich Plasma
Published in Rubina Alves, Ramon Grimalt, Techniques in the Evaluation and Management of Hair Diseases, 2021
Lu Yin, Katerina Svigos, Kristen Lo Sicco, Jerry Shapiro
Many PRP preparation systems utilize centrifugation to separate and concentrate the platelets found in whole blood. Companies with commercially available PRP preparation systems include Regen Lab SA (Le Mont-sur-Lausanne, Switzerland), Eclipse Aesthetics, LLC (Colony, TX, USA), DTS MG Co., Ltd. (Seoul, Korea), Arthrex, Inc. (Naples, FL, USA), and Factor Medical, LLC (Langhorne, PA, USA). Machines vary according to rotation speed, force, and spin time, ultimately resulting in different platelet concentrations [13]. Though manuscripts exist in the literature discussing the properties of different centrifuges and variations in platelet and growth factor concentrations for different PRP preparation systems, data is scarce, and there is no consensus regarding an optimal protocol [13, 14].
PRP in Vitiligo
Published in Vineet Relhan, Vijay Kumar Garg, Sneha Ghunawat, Khushbu Mahajan, Comprehensive Textbook on Vitiligo, 2020
Platelet-rich plasma (PRP) refers to a high concentration of platelets that are concentrated into a small volume of plasma. The concept was first popularized by Whitman in 1997 and Marx et al. in 1998 in oral and maxillofacial surgery for regenerative medicine [1,2]. PRP is currently widely used in various fields of dermatology, from chronic ulcer management to trichology and aesthetics, due to its role in wound healing.
Efficacy of autologous platelet-rich plasma therapy versus topical Minoxidil in men with moderate androgenetic alopecia: a randomized open-label trial
Published in Journal of Dermatological Treatment, 2023
Mithinkumar Balasundaram, Rashmi Kumari, Sivaranjini Ramassamy
The overall incidence of adverse events was similar between treatment groups, 37% in Minoxidil arm and 53% in PRP arm (p = 0.21). Most of the adverse events were mild in Minoxidil arm. The common side effects were mild headache (n = 4) and scalp pruritus (n = 4). Three of the subjects experienced dryness of the scalp following minoxidil use. One of them experienced allergic contact dermatitis to the vehicle, presenting as erythema and a burning sensation over the hairline after one week of use. The episode resolved with topical steroid application in a week. He withdrew from the study, despite the advice to change the formulation. The pain was the most common side effect (n = 17) associated with PRP injection. This usually lasted for up to 4–5 h post-procedure. Five of them needed a painkiller for relief, while the remaining could tolerate it. Four patients refused further sessions after the second sitting, as they could not tolerate the pain post-injection. All of them presented for assessment at week 12.
Mass cytometry of platelet-rich plasma: a new approach to analyze platelet surface expression and reactivity
Published in Platelets, 2022
Melissa Klug, Kilian Kirmes, Jiaying Han, Olga Lazareva, Marc Rosenbaum, Giacomo Viggiani, Moritz von Scheidt, Jürgen Ruland, Jan Baumbach, Gianluigi Condorelli, Karl-Ludwig Laugwitz, Markus List, Isabell Bernlochner, Dario Bongiovanni
PRP generation is a common technique in platelet research to concentrate platelets from peripheral blood minimizing the risk of contamination from other cells. It has been proven suitable for platelet research including reactivity studies [14–17]. Recently, PRP has also been used for the first time in mass cytometry studies examining platelet reactivity and investigating platelet subtypes during SarsCoV2 infection and after BNT162b2 vaccination[8,18]. PRP generation from whole blood has been described by several groups before; with the use of the different platelet inhibitors it is quick, simple and reliable as it allows to avoid cell contamination and to maintain thrombocyte reactivity. The use of PRP in mass cytometry allows to save rather expensive CyTOF-antibodies in a high-concentrated platelet solution. On the contrary, staining whole blood, which is characterized by a low platelet concentration wastes cell material and antibodies leading to fewer recorded platelet events in longer time of measurement[1]. With our method along with following the state-of-the-art clean-up protocol using gaussian parameters (Maxpar protocol), it is possible to acquire 300,000 to 500,000 events which enables the investigation of extremely small platelet subgroups of the entire platelet population [19,20]. This is of particular importance as platelets are, in comparison to other cells, a rather homogeneous group. Thus it is necessary to acquire a high number of cells in order to achieve the desirable power to perform suitable bioinformatic analyses.
Evaluation of platelet-rich plasma efficacy in melasma
Published in Journal of Cosmetic and Laser Therapy, 2022
Ayda Acar, Ayris Ozturk, Nur Sokmen, Idil Unal, Ilgen Ertam Sagduyu
PRP contains plenty of platelets in a small amount of plasma. Platelets contain several growth factors (platelet-derived growth factor [PDGF], transforming growth factor beta [TGF-β], insulin-like growth factor [IGF], keratinocyte growth factor [KGF], epidermal growth factor [EGF], fibroblast growth factor [FGF], vascular endothelial growth factor [VEGF]) and cytokines in α-granules. PRP can be used in hair loss, skin ulcer, acne scar treatment and skin rejuvenation. Also, PRP has been used in the treatment of melasma in recent years. PRP effect on melasma is depending on α-granules of platelets containing TGF-β, EGF, PDGF. TGF-β has the major role on inhibiting melanogenesis (2,3). In a study, authors observed that TGF- β levels in skin biopsies increased after PRP administration in patients with melasma who had low TGF- β levels before PRP treatment (2). In this study, we aimed to determine the efficacy of PRP in melasma.