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Assessment of iron-restricted erythropoiesis in chronic renal disease: evaluation of Abbott CELL-DYN Sapphire mean reticulocyte hemoglobin content (MCHr)
Published in Scandinavian Journal of Clinical and Laboratory Investigation, 2019
Eloísa Urrechaga, Johannes J. M. L. Hoffmann
Instrument-specific reference ranges [15,16] and clinical decision values for a number of conditions have been established. This is regarded necessary, due to the differences in technology mentioned and the lack of international standardization of these new RBC and reticulocyte parameters. It has been demonstrated that MCHr measured by CELL-DYN Sapphire can accurately detect a negative iron balance and suboptimal hemoglobinization in early stages of iron depletion in blood donors, in latent iron deficiency and in inflammatory diseases [17–19].