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Obstetrics: Answers
Published in Euan Kevelighan, Jeremy Gasson, Makiya Ashraf, Get Through MRCOG Part 2: Short Answer Questions, 2020
Euan Kevelighan, Jeremy Gasson, Makiya Ashraf
BMI >30, previous history, large baby, family history, ethnic origin.Oral glucose tolerance test.
Clinical specialties
Published in Andrew Schofield, Paul Schofield, The Complete SAQ Study Guide, 2019
Andrew Schofield, Paul Schofield
A 28-year-old gravida 2 parity 1 attends your clinic after the midwife had repeated positive urine dipstick tests for glucose. An oral glucose tolerance test was performed prior to clinic, and it confirmed gestational diabetes. She had not been known to have diabetes prior to becoming pregnant. Name three risk factors for developing gestational diabetes? (3)Explain the mechanism behind the development of a macrosomie baby in diabetic pregnant women? (2)Name risks to the foetus in women who suffer diabetes (gestational or established) during pregnancy? (2)What is the commonest complication in the neonate post delivery? (1)She is worried that she may suffer diabetes in the future.What will you tell this lady? (2)
The Child With Diabetes Mellitus
Published in Michael B O’Neill, Michelle Mary Mcevoy, Alf J Nicholson, Terence Stephenson, Stephanie Ryan, Diagnosing and Treating Common Problems in Paediatrics, 2017
Michael B O’Neill, Michelle Mary Mcevoy, Alf J Nicholson, Terence Stephenson, Stephanie Ryan
An oral glucose tolerance test is rarely needed, except in atypical cases or very early disease in which plasma glucose levels are normal. A 75 g glucose load should be given and blood glucose measured 2 hours post administration.
Chebulagic acid attenuates HFD/streptozotocin induced impaired glucose metabolism and insulin resistance via up regulations of PPAR γ and GLUT 4 in type 2 diabetic rats
Published in Toxicology Mechanisms and Methods, 2022
Ganesh Vasu, Ramalingam Sundaram, Karuppiah Muthu
We had conducted an oral glucose tolerance test to confirm further the effective dose of chebulagic acid in lowering glucose. Results of the oral glucose tolerance test conducted on normal and different experimental groups are shown in Figure 1. The blood glucose level in both normal and drug-alone treated control rats showed a high peak value at 30 and 60 min after glucose load and reached the fasting levels at 120 min. In the diabetic rat, the blood glucose levels reached the peak value at 30, 60 min and remain higher even after 120 min but in the case of different concentrations of hebulagic acid-treated diabetic rats, prevented the rise of blood glucose levels significantly in a dose-dependent manner. The maximum glucose-lowering effect of chebulagic acid was observed at a dose of 50 mg/kg b.wt than the other two doses (25 and 100 mg/kg b.wt.) at 120 min which were similar to that of metformin- used as a reference antidiabetic drug. Normal rats treated with chebulagic acid at a dose of 100 mg/kg b.wt did not alter the parameters tested, likewise, diabetic rats treated with chebulagic acid at a dose of 25 and 100 mg/kg b.wt did not bring a significant glucose-lowering effect which was not comparable to that of metformin-treated diabetic rats. Hence, these three groups were omitted and not included in further studies.
Inflammatory state does not affect the antiplatelet efficacy of potent P2Y12 inhibitors in ACS
Published in Platelets, 2021
Benedikt S. Biesinger, Aleksandra Gasecka, Thomas Perkmann, Johann Wojta, Maciej Lesiak, Marek Grygier, Ceren Eyileten, Marek Postuła, Krzysztof J. Filipiak, Aurel Toma, Christian Hengstenberg, Jolanta M. Siller-Matula
The following data were recorded on admission: demographic data (age, gender), weight, type of ACS and type of P2Y12 inhibitor administered (prasugrel, ticagrelor), cardiovascular risk factors (arterial hypertension, hyperlipidemia, smoking status, family history of coronary artery disease and diabetes mellitus), history of cardiovascular disease (prior AMI, prior PCI, carotid artery disease, peripheral artery disease), angiographic data, and pharmacotherapy administered at admission. Arterial hypertension was defined as (i) a history of hypertension and/or the use of antihypertensive drugs or (ii) repetitive resting blood pressure values above 140/90 mmHg during in-hospital measurements, applied two to four times daily. Hyperlipidemia was defined as (i) a history of lipid-lowering therapy or (ii) total cholesterol level above 200 mg/dl. Smoking was assessed as current, past, and nonsmoking. Diabetes mellitus was defined as (i) pathological oral glucose tolerance test, or (ii) a history of diabetes or anti-diabetic therapy. On admission, HbA1 c was measured in all patients and oral glucose tolerance test was performed, if necessary, to detect undiagnosed diabetes. In addition, routine laboratory parameters were recorded.
Longterm effects of rotational night shift work on expression of circadian genes and its association with postprandial triglyceride levels – A pilot study
Published in Chronobiology International, 2021
M Aslam, SV Madhu, K Keithellakpam, M Mehndiratta, BK Mishra, V Neh
Study participants were called one week after the oral glucose tolerance test for laboratory study (blood sampling for various parameters) scheduled at 08:00 h. Between the one week interval of the oral glucose tolerance test and the laboratory study, it was ensured that none of the study participants engaged in night shift duty. In addition, participants were asked to follow the following instructions: (i) during this week and on the morning of the laboratory study, obtain a minimum of 15 min exposure to outdoor natural light within 90 min of waking up to strengthen the regularity of their circadian rhythm; (ii) commencing two days prior to the laboratory study refrain from alcohol, caffeine, and heavy exercise; and (iii) on the day prior to the laboratory study refrain from foods and drinks other than water before consuming a standard dinner between 18:00 and 19:00 h and thereafter fasting for 12 h.