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Diseases of the Nervous System
Published in George Feuer, Felix A. de la Iglesia, Molecular Biochemistry of Human Disease, 2020
George Feuer, Felix A. de la Iglesia
There are striking differences in the consequences of lesions due to histidinemia or phenylketonuria. The lower incidence of severe subnormality in histidinemia may be related to the higher renal clearance of histidine as compared to phenylalanine. Histidinemic children have about 10 times higher histidine levels in the blood than normal adults or children, whereas serum phanylalanine rises 20 or 50 times above normal levels. Furthermore, the accumulated tissue histidine and its metabolites may exert less cytotoxic action or inhibition of enzymes in related metabolic pathways.
Quartz crystal microbalance based histidine sensor
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Merve Sönmezler, Erdoğan Özgür, Handan Yavuz, Adil Denizli
Histidine, an essential bioactive molecule, is highly important for human growth and repair of tissues and behaves as a neurotransmitter in human muscular and the central nervous system [1–5]. Additionally, histidine regulates metal ions transmission in biological systems and constitutes the active site of many enzymes and natural proteins [6,7]. Hence, excessive or deficiency of histidine/histidine rich proteins would cause many diseases like Parkinson’s disease [2], epilepsy [8], histidinemia [9], chronic kidney disease [5], the failure of normal erythropoiesis development [10], inflammation and oxidative stress [5,11]. Sensitive, specific and accurate detection of histidine in biological samples has great significance in clinical analysis. The low concentration and similar structural features of other amino acids bother the specific detection of histidine in many biological samples. Various analytical methods including capillary electrophoresis, HPLC, colorimetry, fluorometry, SERS, NMR and electrochemistry [4,12–17] have been proposed to overcome this challange. Some of these analytical methods suffer from the complicated operating procedures, complicated instrumentation, sophisticated detection systems and expensive cost [3].