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Treatment Algorithm for Acne Scars
Published in Antonella Tosti, Maria Pia De Padova, Gabriella Fabbrocini, Kenneth R. Beer, Acne Scars, 2018
Daniele Innocenzi, Ilaria Proietti, Concetta Potenza, Patrick M. Zito, Kenneth R. Beer
The first energy source in this arena was the monopolar RF device, ThermaCool (Thermage, Inc, Hayward, CA, USA), which demonstrated improvement in skin laxity and acne scars. The most recent development is the Accent device (Alma Lasers, Ltd, Caesarea, Israel), which offers alternatively bipolar and a novel unipolar RF modes [84]. The treatment of photoaging through non-ablative photorejuvenation encompasses the use of photodynamic therapy [85,86]. The application of topical photosensitizers, namely 5-5-aminolevulinic acid (ALA), for short incubation times combined with newer laser and light sources has been shown to be safe and effective. It may have a role in the collagen growth and thus in improvement of atrophic scars.
Photoaging
Published in Henry W. Lim, Nicholas A. Soter, Clinical Photomedicine, 2018
Barbara A. Gilchrest, Gary S. Rogers
Photoaging is the term used to describe the clinical, histologic, and functional changes in chronically sun-exposed skin of middle-aged and elderly adults. Terms previously used in the medical literature and lay press as synonyms include premature aging, accelerated aging, dermatoheliosis, heliodermatitis, chronic sun damage, and even aging itself. The confusion between intrinsic or chronologic aging and photoaging is understandable, as the two processes have much in common, although detailed comparison reveals both quantitative and qualitative differences (1).
Effects of solar radiation, air pollution, and artificial blue light on the skin
Published in Roger L. McMullen, Antioxidants and the Skin, 2018
Before continuing the discussion of photoaging, we should first discuss some of the effects associated with normal skin aging. Table 4.2 provides a list of some of the histological features associated with aged skin.
Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells
Published in Drug Delivery, 2022
Yijin Wang, Qianqian Ouyang, Xuefei Chang, Min Yang, Junpeng He, Yang Tian, Jun Sheng
Ultraviolet (UV) radiation is harmful to human skin and causes tanning, sunburn, immune suppression, cancer, and photoaging (Afnan et al., 2012). Skin photoaging is a common skin disease and its common clinical manifestations include skin elasticity loss, epidermal atrophy, deep wrinkles, and normal pigmentation, which can lead to cell necrosis, apoptosis, or cancer (Walton et al., 2005; Kim et al., 2011). Skin photoaging seriously affects not only the physical appearance and mental quality of life, but it also has an etiological association with the occurrence of skin cancer. Therefore, skin photoaging caused by UV and its related issues has gained considerable interest as a future research topic. Chronic exposure to UVB (280–315 nm) radiation results in the enhanced generation of reactive oxygen species (ROS) in the skin, which leads to oxidative stress and photodamage to macromolecules such as proteins and nucleic acids (Jo et al., 2012). Further, such chronic exposure can cause adverse changes in the extracellular matrix (ECM), which lead to skin photoaging because of the enhanced production of matrix metalloproteinases (MMPs) such as MMP-1, MMP-3, and MMP-9, which is possibly mediated by the augmented ROS production (Gęgotek et al., 2021).
A rutin nanocrystal gel as an effective dermal delivery system for enhanced anti-photoaging application
Published in Drug Development and Industrial Pharmacy, 2021
Jing Li, Weilong Ni, Mayinuer Aisha, Juanjuan Zhang, Minjie Sun
Skin photoaging is a kind of accelerated skin-aging damage resulting from continuous exposure to ultraviolet (UV) radiation, which is mainly characterized by dryness, erythema, deep wrinkles, and pigment formation [1]. UV radiation, actually referring to UVA (320–400 nm) and UVB (275–320 nm), often induces the overproduction of reactive oxygen species (ROS), leading to the destruction of oxidative stress dynamic balance and the accumulation of lipid peroxidation, which is the critical determinant in the formation of skin photoaging [2–4]. In recent years, the risk of photoaged skin has increased sharply due to the deterioration of ozone depletion, which has seriously threatened human health [5]. The application of dermal preparations containing antioxidants is a potent approach to inhibit photoaging caused by UV irradiation.
Topical delivery of l -ascorbic acid spanlastics for stability enhancement and treatment of UVB induced damaged skin
Published in Drug Delivery, 2021
Mona Elhabak, Samar Ibrahim, Samar M. Abouelatta
Premature skin photoaging is one of the most common harmful effects of chronic exposure to UV irradiation (Pallela et al. 2010). Vitamin C is a very potent naturally occurring antioxidant drug. Human body cannot synthesize vitamin C due to the absence of the enzyme l-glucono-gamma lactone oxidase. This represents a major challenge toward utilization of vitamin C which suffers severe stability problems as well as difficulty in delivery to the targeted site (Al-Niaimi & Chiang 2017). Being a cofactor in collagen biosynthesis, vitamin C provides its well-known antiaging and anti-wrinkling activity. This is achieved by increasing collagen synthesis, as well as diminishing collagen degradation, hence melanin production and reduction of skin pigmentation (Rattanawiwatpong et al. 2020).