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Nanoparticle-Stabilized Liposomes as an Effective Bio-Active Drug Molecule Delivery for Acne Treatment
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Catherine Wilkinson, Marco N. De Canha, Namrita Lall
Tretinoin is a common topically administered acne treatment, but is the cause of several adverse effects such as photosensitivity, erythema, peeling, and burning. The activity of tretinoin is negatively affected by instability due to its sensitivity to external factors such as oxygen, low pH and light; this results in unpredictable effectivity due to the ease of removal. Liposome-delivered tretinoin is found to be present at higher concentrations in the dermal and epidermal layers due to its protection from degradation conferred by the liposomes (Rahman et al., 2016). Table 4.4 lists some of the commonly used acne treatments that are administered via liposomes.
Use of Dermatologics during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
A recent review of tretinoin use in pregnancy stated: Although oral exposure of pregnant animals to high doses of third-generation retinoids results in significant systemic absorption with resultant retinoid embryopathies, topical administration of these molecules, as well as of the earlier generation retinoids formulated for dermal application, results in barely detectible changes in the normal concentrations of total retinoids in the blood. Substantial animal data exist to indicate the relative safety of topically applied retinoids in pregnancy and the limited epidemiologic data available to date support this conjecture(Williams et al., 2020) ACOG has a more conservative position, urging avoidance of retinoids in pregnancy when possible (ACOG, 2020).
Oral Diseases
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Marcia Ramos-e-Silva, José Wilson Accioly Filho, Sueli Carneiro, Nurimar Conceição Fernandes
Management: As it is generally asymptomatic, it requires treatment only, when there is discomfort. There may be a candidal or bacterial infection, so antifungal and/or antimicrobials may be helpful. It has no premalignant potential and can improve spontaneously or with zidovudine; there are still patients who benefit from acyclovir. A few applications 25% podophyllin can be helpful. Topical tretinoin can also be applied two or three times a day until the lesions disappear. Cryotherapy is an alternative, but it is not widely used. Unfortunately, recurrence is a problem.
A comparison study of the 0.1% tretinoin cream versus fractional microneedle radiofrequency combination with fractional CO2 laser for the treatment of striae alba in Indonesian patients
Published in Journal of Cosmetic and Laser Therapy, 2021
M. Yulianto Listiawan, Cita Rosita Sigit Prakoeswa, Linda Astari, Iskandar Zulkarnain, Putri Hendria Wardhani, Densy Violina Harnanti
Changes in the percentage of collagen area before (pre) and after (post) showed a significant difference between pre and post therapy in each group (Figure 3 and Figure 4). An increase in collagen is also obtained in the 0.1% tretinoin cream after 3 months of therapy, that is faster than previous studies that took time minimum of 6 months (15, 21). This is also in accordance with the research of Ryu et al, who conducted a study on patients with striae distensae using FMR and fractional CO2 laser, there was an increase in collagen in SA lesions after research subjects received 3x FMR and fractional CO2 laser therapy (7). Data on differences in changes in the percentage of collagen area (%) results showed a significant difference in changes in the percentage of collagen area (%) between groups (p = .019).
Liposome-based combination therapy for acne treatment
Published in Journal of Liposome Research, 2020
İpek Eroğlu, Minela Aslan, Ümran Yaman, Merve Gultekinoglu, Semih Çalamak, Didem Kart, Kezban Ulubayram
In combination therapy options, retinoids are commonly used due to their comedolytic and anti-inflammatory effects. These agents bind to retinoic acid receptors and thus lead to the resolving of microcomedone lesions and that is what makes them ideal for comedonal acne (Geng et al.2009, Zaenglein et al.2016). On the other hand, use of retinoids is limited by their side effects such as local irritation, elevated sensitivity to sunlight and stability problems of the active ingredients (Elbaum 1988, Brisaert et al.2001). A member of retinoids, tretinoin is the most commonly used retinoid for acne, but on the other hand, its irritative potential on the applied area and the barrier of the stratum corneum limit its usage. Also, it is affected by the exposure to oxygen, light, and acids; therefore, effectiveness of topical commercial formulations of tretinoin is mainly limited by the barrier properties of the skin, exposure to oxygen, and easy removal from the site of action (Varani et al.2000, Shin et al.2005). For this purpose, Rahman et al. have formulated liposomal formulations of tretinoin to overcome fore-mentioned problems in patients with AV. Their results indicated that liposomal tretinoin formulations provided improved skin tolerability and patients compliance when compared to the commercial gel product with enhanced activity (Rahman et al.2016).
Adverse events related to topical drug treatments for acne vulgaris
Published in Expert Opinion on Drug Safety, 2020
Agnieszka Otlewska, Wojciech Baran, Aleksandra Batycka-Baran
The available topical formulations of tretinoin used for acne are 0.025–0.1% cream, 0.01–0.025% in standard gel, and 0.025–0.1% in vehicles designed to control drug release, increase drug retention in the stratum corneum and inhibit deeper penetration [12]. It is usually administered once daily [12]. There are also formulations containing prepolyolprepolymer-2 which helps to preserve drug particles on the skin surface and in the upper layers of the skin. It has been shown that tretinoin 0.025% gel and 0.025% cream significantly reduces noninflammatory and inflammatory acne lesions in a once daily application manner compared with vehicle by week 12 [22]. The first results of treatment may be seen after 2–3 weeks, but improvement is usually gradual and the majority of the patients need 2–4 months to achieve positive results [12]. The systemic toxicity has not been linked with topical tretinoin [12].