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Conclusions
Published in Rubina Alves, Ramon Grimalt, Techniques in the Evaluation and Management of Hair Diseases, 2021
Microneedling is a relatively new, minimally invasive, procedure involving superficial and controlled puncturing of the skin by rolling with miniature fine needles. Traditionally used as a collagen induction therapy for facial scars and skin rejuvenation, the scope of microneedling has expanded for hair stimulation and for transdermal delivery of therapeutic drugs and vaccines. The various cosmetic uses of microneedles include acne vulgaris, acne scars, skin rejuvenation, and hair growth, as you have been able to learn from Drs. Dhurat and Daruwalla's chapter.
Acne Scarring and Patients of African Descent
Published in Antonella Tosti, Maria Pia De Padova, Gabriella Fabbrocini, Kenneth R. Beer, Acne Scars, 2018
Aldo D. Galvez, Amy J. McMichael
Microneedling is a technique that allows the physician to make many rapid healing punctures, allowing the formation of collagen and elastin as a wound-healing response. Side effects, such as infection or PIH, are minimal as it keeps the epidermis partially intact [51]. Microneedling is usually done with a device called the Dermaroller, with most protocols suggesting rolling the device in four to six different directions in the targeted area. These procedures are usually done every 6 weeks and its safe in patients with dark skin [52]. Some protocols in patients with phototype VI and V combine microneedling treatment with chemical peels as high as 35% which are performed every 6 weeks in between the resting period for microneedling, achieving better results than with microneedling alone and without a significant risk for PIH [53].
Exploring new frontiers in drug delivery with minimally invasive microneedles: fabrication techniques, biomedical applications, and regulatory aspects
Published in Expert Opinion on Drug Delivery, 2023
Niha Sultana, Ayesha Waheed, Asad Ali, Samreen Jahan, Mohd Aqil, Yasmin Sultana, Mohd. Mujeeb
The technique called microneedling, famous among dermatologists these days, is known since twentieth century. It involves the puncturing of the skin with micro-sized needles, stimulating the development of growth factors and collagen. As reported by Ramaut et al. and Alster et al., dermatologists significantly accept the microneedling technique for problems like antiaging, reduction of wrinkles, and as a rejuvenating therapy for smooth and younger looking skin [108]. MNs in the form of derma roller is one of the most utilized ways to tackle skin problems. It is intended to penetrate stratum corneum in order to boost the efficacy of skincare products. They are available in various sizes and designs. Camirand and fellow were the first to observe the healing of scars by needle abrasion of the tissue by using empty tattoo gun on surgical scars [109]. Pahwa et al. have developed a simple derma roller which is drum shaped with eight rows of total 192 MNs for the treatment of acne scars [110]. Additionally, Park et al. have shown improved results in treating dermal scars by developing disc MN therapy system. Microneedling also has beneficial effects in treating hair problems [111]. Microneedling along with the existing treatment strategy has proven to be effective in new hair formation as reported by Dhurat et al. [112].
Efficacy and safety of fractional CO2 laser and tranexamic acid versus microneedling and tranexamic acid in the treatment of infraorbital hyperpigmentation
Published in Journal of Dermatological Treatment, 2022
Reza Ghandehari, Reza M. Robati, Nasim Niknezhad, Nastaran Hajizadeh, Zohreh Tehranchinia
POH can be a significant cosmetic problem, but there is not enough attention to this issue in the literature and the need for further researches is quite notable. Previous studies have evaluated various types of lasers for treatment of pigmentary disorders with different effects, e.g. Q-switched lasers, pulsed-dye lasers, traditional ablative lasers, ablative fractional lasers, and non-ablative fractional lasers. Resurfacing lasers, e.g. carbon dioxide (CO2) or erbium:YAG can be efficient therapeutic options for the treatment of the patients with POH complaints. They have many effects on target tissue such as stimulating collagen production, tightening of skin, and pigment lightening (4–7). Microneedling is a novel therapeutic modality in dermatology. Dermatologists employ it for the treatment of multiple cosmetic and dermatologic conditions as a relatively low cost and minimally invasive tool. The basis of microneedling relies on physical trauma. It is shown that the trauma generated by needle penetration into the skin can induce regeneration of the dermis (8). In addition, microneedling increases the penetration of various topical medications through skin barriers (9). Several surveys have also been assessed the efficacy of topical tranexamic acid (TA), which alleviates ultraviolet radiation-induced melanogenesis and neovascularization by inhibiting plasminogen activation (10).
Efficacy of local prostaglandin analogues for vitiligo treatment: a systematic review and meta-analysis
Published in Expert Review of Clinical Pharmacology, 2022
Owing to restrictions regarding the study designs for including trials, we could perform limited types of pooled analysis to elucidate the efficacy of prostaglandin analogues in comparison with some commonly used local therapies for vitiligo. One study by Grimes included in our systematic review found that combination therapy with topical bimatoprost and mometasone provided greater repigmentation than did each topical agent alone [11]. Furthermore, Anbar et al demonstrated better clinical improvement after topical latanoprost alone compared with NB-UVB phototherapy, but the statistical significance was not determined [10]. In addition, two of our included studies involved microneedling before the application of topical medications. Microneedling is a minimally invasive technique used to create microwounds in the skin, which might induce skin tissue remodeling and enhance the absorption of topical agents [22]. Because of the equivalent designs of intervention and comparator groups, we could not determine the independent effects of microneedling in these two studies [16,21]. Another prospective right–left comparative study by Stanimirovic et al revealed that microneedling provided no additional effects on repigmentation for the combination therapy of topical latanoprost solution with NB-UVB phototherapy [23]. More head-to-head studies are warranted to determine the efficacy of topical prostaglandin analogues alone in comparison with topical corticosteroids, NB-UVB phototherapy, or excimer light for vitiligo treatment.