Erythema annulare centrifugum

Erythemas

Published in Aimilios Lallas, Enzo Errichetti, Dimitrios Ioannides, Dermoscopy in General Dermatology, 2018

Nicola di Meo, Paola Corneli, Iris Zalaudek

The term “erythema annulare centrifugum” refers to a number of chronic annular and erythematous skin eruptions resulting from a type IV hypersensitivity reaction to several factors, such as malignancies, infections, drugs, immunological disorders, etc.4 There are two main clinicopathologic variants, namely, “superficial” form (Wende type) and “deep” form (Darier type), with a perivascular lymphohistiocytic infiltrate respectively localized in papillary/mid dermis and reticular dermis.4

Eosinophilic annular erythema

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Journal Information

Published in Baylor University Medical Center Proceedings, 2021

Nicole Dacy, Kyle Oney, Katherine Fiala, Palak Parekh

Our patient’s case was also not consistent with other entities on our differential. Granuloma annulare typically affects the dorsal hands and feet with only one or two lesions and less commonly presents with generalized involvement. Histologically, granuloma annulare is characterized by a palisading granuloma with histiocytes and epithelioid cells surrounding a central zone of altered collagen.8 Erythema annulare centrifugum is the most common gyrate erythema with a characteristic trailing scale at the inner border of the erythema. Histologically, the epidermis will show mild spongiosis and parakeratosis, with the superficial dermis showing lymphocytes tightly around the blood vessels in a “coat sleeve” pattern.9 Sarcoidosis is known as a “great imitator,” and cutaneous annular sarcoidosis could have a similar clinical appearance to EAE. However, histology would show noncaseating granulomas.10

Erythema annulare centrifugum

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Erythemas

Eosinophilic annular erythema