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Dermal filler complications and management
Published in Michael Parker, Charlie James, Fundamentals for Cosmetic Practice, 2022
Fungal skin infections on the whole are relatively common; however, relatively few affect the skin of the face. Most fungi exhibit a preference for warm, moist areas such as oral mucosa or creases in the groin. Fungal infections of the skin can be divided in respect to their depth, classified as either superficial mycoses affecting the outer epidermis or hair; cutaneous mycoses of the deep epidermis and hair follicles or nails; and subcutaneous mycoses of the fat, muscle and fascia. Of these three superficial and cutaneous mycoses are by far the most common. Systemic fungal infections are rare unless a person is immunocompromised, which we shall explain in more detail later in this chapter. Other important risk factors for a fungal infection include poor hygiene, damage to mucosal barriers and the recent use of antibiotics.
Endocrinology and gonads
Published in Jagdish M. Gupta, John Beveridge, MCQs in Paediatrics, 2020
Jagdish M. Gupta, John Beveridge
11.10. Recognized complications of long-term therapy with prednisolone in childhood includegrowth retardation.postural hypotension.exacerbation of fungal infection.proximal myopathy.peripheral neuropathy.
Dermatomycoses
Published in Raimo E Suhonen, Rodney P R Dawber, David H Ellis, Fungal Infections of the Skin, Hair and Nails, 2020
Raimo E Suhonen, Rodney P R Dawber, David H Ellis
Tinea pedis (Figures 2.1–2.6) is a fungal infection of the foot that may involve the toe webs. It is often called athlete’s foot and is the most common fungal infection. Hot, moist climates are particularly conducive to clinical manifestation. Genetic predisposition is known to occur for plantar type of tinea pedis.
Assessment of antifungal efficacy of itraconazole loaded aspasomal cream: comparative clinical study
Published in Drug Delivery, 2022
Caroline Lamie, Enas Elmowafy, Maha H. Ragaie, Dalia A. Attia, Nahed D. Mortada
Herein, the antifungal potential against DD complicated by candidiasis, TC, and TVC was evaluated clinically. Direct assessment of patients suffering from these fungal infections was performed, reporting response, tolerability, and apparent side effects. As the marketed ITZ cream (1%) was not available in Egypt at the time the clinical investigation was conducted, we incorporated ITZ in the prepared cream base at the same concentrations as the proposed aspasomal cream for the sake of comparison. The proposed aspasomal cream was compared with cream enclosing non-formulated ITZ, placebo (plain aspasomal cream) and control (cream base) formulae. More importantly, the impact of attempting two ITZ concentrations (0.1 and 0.5%), being lower than that utilized in the market (1%) was demonstrated.
Repurposing of atorvastatin emulsomes as a topical antifungal agent
Published in Drug Delivery, 2022
Alaa S. Eita, Amna M. A. Makky, Asem Anter, Islam A. Khalil
Fungal infections are one of the highly insecure health issues faced by healthcare professionals. Statistics recorded about 13 million infections and ∼1.5 million deaths worldwide yearly. One of the main causes of this alarming rate is the noticeable elevation in the immunocompromised patient population (Rayens & Norris, 2022). Candidiasis is one of the most prevalent diseases affecting patients globally, including various types such as mucosal candidiasis, systemic candidiasis, vaginal candidiasis, and cutaneous candidiasis (Kauffman et al., 2011). Cutaneous candidiasis can be treated with several antifungal classes such as azole, allylamine, and polyene antifungals. Nowadays drug resistance and adverse effects are revealed as an obvious challenge for those conventional antifungal drugs. Therefore, prospective studies and drug development are in demand (de Oliveira Santos et al., 2018).
Anticandidal activity of green synthesised silver nanoparticles and extract loaded chitosan nanoparticles of Euphorbia prostata
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2022
Jean P. Dzoyem, Roland T. Tchuenguem, Jamshed Iqbal, Muhammad Arfat Yameen, Abdul Mannan, Irum Shahzadi, Tariq Ismail, Nighat Fatima, Ghulam Murtaza
Human fungal infections pose serious medical issues. During the last decade, the incidence of superficial and systemic fungal infections has continued to increase explosively, due to the increasing number of immunocompromised persons, affecting millions of people worldwide [6]. The use of synthetic chemicals for controlling these fungal infections is not the most secure method because of the reported toxic effects of these chemicals and the development of resistance against them [7,8]. Therefore, it is necessary to search for novel treatment options with improved features, and green synthesized NPs are an alternative. NPs are known to have extremely large surface areas which provide good contact and interaction with microbes, thus contributing to their good antimicrobial activity [1]. Nanoscale materials have emerged as novel antifungal agents, owing to their high surface area to volume ratio and their unique chemical and physical properties [9].