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Management of Natural Rubber Glove Sensitivity
Published in Robert N. Phalen, Howard I. Maibach, Protective Gloves for Occupational Use, 2023
Allergic contact dermatitis is the immune-mediated form of contact dermatitis and occurs in previously sensitized individuals. It requires a sensitization phase which occurs during the initial exposure to the allergen and lasts for 10–14 days. Re-exposure to the sensitizing substance leads to the development of papulovesicular lesions with erythema over the site of contact with allergen within 24–48 h, which is called the elicitation phase. Xerosis, fissures, and lichenification can be seen in chronic cases.
Patient assessment
Published in Michael Parker, Charlie James, Fundamentals for Cosmetic Practice, 2022
The management of allergic contact dermatitis can be difficult simply because it can be hard to ascertain what the causative allergen is. Patients with suspected allergic contact dermatitis with no obvious trigger are commonly referred for patch testing to investigate this further. Once a causative allergen has been identified then the first line of management is to avoid it if at all possible. Acute flares are managed similarly to any other allergic response, with oral antihistamines such as chlorphenamine and topical steroids such as hydrocortisone comprising the mainstay of treatment. Allergic contact dermatitis respects the first rule of dermatology: “If it is dry, make it wet. If it is wet, make it dry” in that acute, weeping responses may benefit from the administration of topical agents to dry them out such as an aluminium acetate astringent, whereas dry, lichenified allergic contact dermatitis is usually best managed with a topical emollient.
Onychotillomania (onychophagia, habit tic, median canaliform onychodystrophy)
Published in Robert Baran, Dimitris Rigopoulos, Chander Grover, Eckart Haneke, Nail Therapies, 2021
Cyanoacrylate adhesives, known as “super glue,” applied one to two times a week in order to create an occlusion area overlying the cuticle, has been used with good results after 4–6 months. Susceptible patients must be careful as allergic contact dermatitis may appear.
Comorbidity identification and referral in atopic dermatitis: a consensus document
Published in Journal of Dermatological Treatment, 2022
Javier Ortíz de Frutos, Gregorio Carretero, Raul de Lucas, Susana Puig, Esther Serra, Susana Gómez Castro, Francisco Rebollo Laserna, Estíbaliz Loza, Juan Francisco Silvestre-Salvador
Concerning allergic contact dermatitis: In AD, at the first visit/s and periodically during follow-up, allergic contact dermatitis should be actively ruled out, in both children and adults (LE 5; GR D; LA 83%)The impact of allergic contact dermatitis on AD patients should be carefully assessed, as it could significantly differ depending on the age at diagnosis; therefore, the clinical attitude should differ, as well (LE 5; GR D; LA 83%)Allergic contact dermatitis should be suspected if any of the following is present: AD with a poor or torpid clinical course, asymmetric locations, extensive flares, or 'atypical’ clinical forms (LE 5; GR D; LA 100%)
Emerging drugs for the treatment of acne: a review of phase 2 & 3 trials
Published in Expert Opinion on Emerging Drugs, 2022
Siddharth Bhatt, Rohit Kothari, Durga Madhab Tripathy, Sunmeet Sandhu, Mahsa Babaei, Mohamad Goldust
Topical usage of retinoids achieves an effective concentration in the skin and precludes from getting systemic adverse effects. Topical retinoids while targeting the epidermal proliferation, reduces the earliest precursor lesions of acne viz comedone. Thereby, making it the first-line therapy in the management of acne vulgaris currently. Retinoids, especially tretinoin being photolabile should ideally be applied during the night. Adapalene and tazarotene in this respect have the added advantage of being photostable and can be applied during the day. It has additional anti-inflammatory properties due to the inhibition of the lipo-oxygenase pathway and chemotaxis, along with free oxygen radical release from neutrophils. Adapalene at 0.3% has also been shown to reduce scar formation and pigmentation due to acne lesions. Erythema, scaling, pruritus, burning, stinging, dryness and irritation are common side effects. It can rarely lead to allergic contact dermatitis.
Comparison between patch test results of natural dyes and standard allergens in batik workers with occupational contact dermatitis
Published in Cutaneous and Ocular Toxicology, 2022
Eka Devinta Novi Diana, Suci Widhiati, Moerbono Mochtar, Muhammad Eko Irawanto
Occupational contact dermatitis (OCD) is a skin disease caused by contact with certain substances in the workplace. Occupational contact dermatitis is the second most common occupational disease, accounting for 15% of occupational diseases. Most cases of OCD are irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), which is 80% of cases that affect the hands1. OCD is divided into ICD and ACD, both acute and chronic. ICD is a non-immunologic reaction that causes inflammation of the skin. Allergic contact dermatitis is a delayed-type hypersensitivity reaction due to exposure to allergens in sensitised individuals2. OCD remains a global burden whose highly related to repeated allergen and irritant exposure in the long term, with textile dyes substance as one of many risk factors of contact dermatitis3.