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Operative Nutritional Status (Preoperative and Postoperative)
Published in Charles Theisler, Adjuvant Medical Care, 2023
Ascorbic Acid: Ascorbic acid plays an important role in the preoperative and postoperative nutrition of surgical patients.4 During and after surgery, vitamin C levels in the body are measurably decreased and replacement above the normal dietary recommendations is necessary to correct this.5 To enhance wound healing, doses of 300-500 mg/day for a week to 10 days, both preoperatively and postoperatively, are generally considered adequate, although considerably larger amounts have been recommended.6 The authors of one study administered daily doses of 500-3,000 mg.7 Studies have shown that this vitamin can help speed the healing process of wounds and that high doses of vitamin C enhance healing.4 Postoperatively, vitamin C is recommended, not only to augment normal healing, but also to guard against suboptimal healing.8
An Overview of COVID-19 Treatment
Published in Hanadi Talal Ahmedah, Muhammad Riaz, Sagheer Ahmed, Marius Alexandru Moga, The Covid-19 Pandemic, 2023
Saffora Riaz, Farkhanda Manzoor, Dou Deqiang, Najmur Rahman
Fundamentally COVID-19 sick patients were treated with intravenous (IV) vitamin C high dosages with the expectation of recovery of patients. Nonetheless, it is not important for the standard convention because no proof for its viability for COVID-19 diseases was accounted for. At the same time, standard doses of vitamin C are by and large unknown, so its high dosages may result in nausea, cramps, and an expanded danger of the kidney.
The science of ageing
Published in Michael Parker, Charlie James, Fundamentals for Cosmetic Practice, 2022
Alongside its function in stabilising collagen fibres, vitamin C also acts as a potent antioxidant by directly scavenging free radicals caused by either environmental pollutants or due to damage caused by ultraviolet light. Vitamin C also works as an indirect antioxidant by rejuvenating membrane-bound vitamin E, allowing it to continue to function as a lipid-bound free-radical scavenger.
The Vitamin E Isoform α-Tocopherol is Not Effective as a Complementary Treatment in Cancer Treatment: A Systematic Review
Published in Nutrition and Cancer, 2022
Dorothee Retzlaff, Jennifer Dörfler, Sabine Kutschan, Maren Freuding, Jens Büntzel, Jutta Hübner
Heaney et al. support the hypothesis that vitamin C supplementation during cancer treatment may worsen the therapeutic response, by antagonizing the therapeutic efficacy in a model of human hematopoietic cancers (46). These effects of antioxidant administration were also observed In Vivo: Colas et al. reported that alpha-Tocopherol suppresses the tumor sensitivity to anthracycline-treatment in rats (47) while Perrone et al. observed that vitamin C can significantly reduce the activity of bortezomib treatment in mice (48). Additionally Ismail et al. showed that the administration of a mixture of antioxidants (including vitamin C, α-tocopherol, vitamin A and Selenium) during radiotherapy leads to significantly lower levels of apoptosis compared to a control group (49) and therefore to a lower effectiveness of radiotherapy.
The relevant targets of anti-oxidative stress: a review
Published in Journal of Drug Targeting, 2021
Nowadays, some antioxidants (e.g. vitamin C, vitamin E, resveratrol, astaxanthin) have been successfully used in the health care industry, the maximum tolerated dose (MTD) and the recommended dietary allowance (RDA) are visualised in Table 1. Vitamin C [2,3], also known as ascorbic acid, is a water-soluble vitamin. Because of its enediol structure, vitamin C has a strong reducibility and can protect other components of cells from the attack of oxygen free radicals. Similarly, vitamin E [4,5], also known as tocopherol, is a fat-soluble vitamin with phenolic hydroxyl in its structure and obvious reducibility, which plays a certain preventive role in cardiovascular and cerebrovascular diseases. However, it has been reported that excessive vitamin E supplementation, not only does not prevent cardiovascular and cerebrovascular diseases, but may increase overall mortality [6]. The new generation of health antioxidants, represented by resveratrol [7,8] and astaxanthin [9,10], are believed to have significant effects on the treatment of cardiovascular diseases, among which the antioxidant activity of astaxanthin is about 6000 times that of vitamin C [11–13]. Although these antioxidants for health care have achieved good results in basic research, unfortunately, they have not been found to have the effect of prevention and treatment of diseases in clinical practice, even some antioxidants that are overused have certain side effects.
Could Vitamin C Protect Against Mercuric Chloride Induced Lung Toxicity In The Offspring Rat: A Histological And Immunohistochemical Study
Published in Ultrastructural Pathology, 2021
Omnia I. Ismail, Manal M.S. El-Meligy
Vitamin C (L-ascorbic acid) is one of most known antioxidants and has DNA protecting affinity.10 Extensive clinical reviews suggested that the involvement of vitamin C in significant decreasing the incidence of the cardiovascular diseases, stroke, kidney injury, malignancy development, and infections as severe respiratory infections.11 One of the key mechanisms responsible for HgCl2 toxicity is oxidative stress. So, the application of antioxidants in several degenerative disorders related to the oxidative stress is becoming widespread used.12 Based on the registered antioxidant effect of vitamin C especially in relation to endothelial dysfunction, we hypothesized that vitamin C may have a protective effect against HgCl2. Therefore, the present study was designed to assess the effect of HgCl2 prenatal exposure on the lung development and probable prophylactic effect of vitamin C.