China
Africa
Explore chapters and articles related to this topic
Role of Curcuma longa and Its Constituents, Especially Curcumin, in Prevention and Management of Diseases
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Numerous research articles show a broad-spectrum range of pharmacological activities including anti-inflammatory, antioxidant, antiseptic, analgesic, antimicrobial, antifungal, antiviral, antimalarial, anticarcinogenic, chemopreventive, proapoptotic, antiparasitic, hepatoprotective and chemotherapeutic activity possessed by Curcuma longa due to the chemical compound curcumin present in it (Çıkrıkçı & Mozio, 2008). Furthermore, strong evidence suggests the immunomodulatory potential of the spice curcumin. It has been found that curcumin regulates the activation of B cells and T cells, macrophages, natural killer (NK) cells, neutrophils and dendritic cells (DCs), as well as the secretion of immune cytokines in the human body (Ahmed et al., 2015; Momtazi et al., 2016; Cundell & Wilkinson, 2014; Seyedzadeh et al., 2014). Table 20.1 shows the description of some of the pharmacological properties of curcumin
Herbal Treatment for Irritable Bowel Syndrome
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Hasya Nazh Ekin, Didem Deliorman Orhan
Curcuma longa species (turmeric) are used in traditional medicine for colds, cough, sinusitis, rheumatism, and skin diseases. Rhizomes of the plant include important secondary metabolites (carbohydrates, proteins, essential oil, polypeptides, curcuminoids) with curative properties.
Medical Therapies
Published in Nazar N. Amso, Saikat Banerjee, Endometriosis, 2022
Simone Ferrero, Fabio Barra, Giulio Evangelisti, Matteo Tantari
Curcumin is a polyphenolic molecule derived from Curcuma longa with antioxidant, anti-inflammatory and antiangiogenic properties (138). This also mitigates VEGF and MMP-3 expression and decreases the production of inflammatory molecules, such as IL-6, IL-8, MIF, MCP-1, VCAM-1 and ICAM-1 in cultures of human ectopic endometriotic stromal cells (139–141). In vivo curcumin demonstrated to decrease the size of endometriosis implants (142). Specifically, the effect on the apoptotic pathway of curcumin was studied in mice in comparison with colecoxib. Curcumin increased the Bax/Bcl-2 ratio and the expression of p53 of stromal and epithelial endometriotic cells significantly more than the COX-2 inhibitor (141). Recently, it was shown that the combination of curcumin and deferoxamine, an iron-chelating agent, reduces implant size and cell proliferation in rats with endometriosis (143).
Curcumin improves the ability of donepezil to ameliorate memory impairment in Drosophila melanogaster: involvement of cholinergic and cnc/Nrf2-redox systems
Published in Drug and Chemical Toxicology, 2023
Opeyemi Babatunde Ogunsuyi, Olayemi Philemon Aro, Ganiyu Oboh, Olawande Chinedu Olagoke
Due to growing focus on ethnobotanicals and their associated health advantages, the usage of nutraceuticals, nutritional supplements, and functional foods has grown greatly over the past years. (Das et al. 2012, Hewlings and Kalman 2017, Santini et al. 2017, Kunnumakkara et al. 2018). Additionally, ethnobotanicals are often thought to be less harmful than synthetic materials (Goel et al. 2008). Turmeric (Curcuma longa), a curry spice made from plants, is known for its therapeutic benefits (Hewlings and Kalman 2017). Numerous turmeric nutritional supplements with various formulations have been made available on the international market with different health claims, including the preventing joint pains, helping to promote locomotion, improving cognitive performance, and providing benefits for cardiovascular function (Goel et al. 2008, Das et al. 2012, Hewlings and Kalman 2017, Santini et al. 2017, Kunnumakkara et al. 2018). Due to its medicinal potential as an cytoprotective, antihyperglycemic and neuroprotectibe compound, curcumin (the primary polyphenol present in turmeric) has received a lot of attention recently (Araújo and Leon 2001, Anand et al. 2007, Goel et al. 2008, Gupta et al. 2013).
Drug discovery strategies for modulating oxidative stress in gastrointestinal disorders
Published in Expert Opinion on Drug Discovery, 2020
Taraneh Mousavi, Nastaran Hadizadeh, Shekoufeh Nikfar, Mohammad Abdollahi
Curcumin, a polyphenolic derivate of Curcuma longa, is favored for its anti-oxidative, anti-inflammatory, anti-bacterial and anti-fungaleffects. Due to its liposoluble nature, it maintains mitochondrial and epithelial membrane under inflammatory/oxidative stress conditions through using lipophilic integration, preserving tight junctions and cytoskeletal proteins, affecting mitochondrial transcription factor, and directly neutralizing free radicals [25]. A recent 21-day study on 540 ducks under ochratoxin A-induced OS, revealed the high potency of curcumin supplementation (400 mg) in getting activity of GPx and SOD and level of MDA, total antioxidant capacity and inflammatory cytokines closer to the control group [188]. Similarly, curcumin improved the OS condition in colitis-associated colorectal cancer models, although it was not considerable [189].
What is the selection process for osteoarthritis pharmacotherapy?
Published in Expert Opinion on Pharmacotherapy, 2020
Shirley P. Yu, David J. Hunter
Nutraceuticals are popular with their direct marketing and labeling of the products stating its potential benefits for specific chronic conditions. The use of fish oil, vitamin D, glucosamine, chondroitin sulfate are all discouraged in OA guidelines. There is limited evidence of their efficacy in OA, and glucosamine, the most commonly used supplement is now strongly recommended against by OA guidelines [13]. There are concerning publication biases in glucosamine trials with a trend toward a larger effect size in industry-sponsored trials [39]. Lately, there has been more topical focus toward curcumin, the principal curcuminoid extracted from turmeric root (curcuma longa). Curumin is thought to be an inhibitor of nuclear factor-kappa β (NF- κβ) and may have pain reduction effects in OA. A recent double-blind multi-center, randomized placebo controlled trial of a bio-optimized curcuma longa extract showed a significant decrease in knee OA pain, with positive trends for Patient Global Assessment of Disease Activity and serum sColl2-1, a biomarker of cartilage degradation [40]. The study is of short duration with 150 participants, and further large-scale investigational trials are required before conclusive recommendations can be made for this nutraceutical.