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Testicular Cancer
Published in Karl H. Pang, Nadir I. Osman, James W.F. Catto, Christopher R. Chapple, Basic Urological Sciences, 2021
Selma Masic, Abhishek Srivastava, Alexander Kutikov
Microscopically:Eosinophilic cells.Extracellular Reinke crystals: dark pink, cigar-shaped.Stain negative for PLAP, AFP, hCG.Stain positive for inhibin, calretinin.
Ovarian steroid cell tumor (not otherwise specified) with subsequent spontaneous pregnancy after tumor removal: a case report and literature review
Published in Gynecological Endocrinology, 2023
Phawat Matemanosak, Krantarat Peeyananjarassri, Chitkasaem Suwanrath, Saranya Wattanakumtornkul, Satit Klangsin, Ekasak Thiangphak, Kanet Kanjanapradit
Pathological examination of the surgical specimen revealed a well-circumscribed left ovarian mass measuring 6 × 6 × 6 cm. The cut section of the specimen exhibited a lobulated and yellowish color (Figure 3a). Histological findings revealed large polygonal tumor cells with abundant granular eosinophilic cytoplasm, round nucleoli, and a prominent central nucleolus (Figure 3b). Tumor cells were arranged in a diffuse pattern separated by fibrous septa, without nuclear atypia or mitotic figures, and no Reinke crystals were identified (Figure 3c). The cells were negative for mucin, periodic acid-Schiff, and periodic acid-Schiff diastase. Immunohistochemistry findings showed that the cells were positive for inhibin (Figure 3d) but negative for AE1/AE3 and cluster of differentiation 68. These findings are consistent with those of steroid cell tumors.
Occult symptomatic bilateral pure Leydig cell tumors in a postmenopausal woman: a case report
Published in Gynecological Endocrinology, 2021
S. Ahmed Hussain, Elizabeth A. Dubil, Javier N. De Luca-Johnson, Michael Johnston
On pathologic gross examination, sectioning of the right ovary revealed a well-circumscribed soft tan-yellow mass within the ovarian cortex measuring 1.0 × 0.9 × 0.8 cm. Sectioning of the left ovary revealed no discrete masses or lesions. On microscopic examination, the right ovarian mass was composed of sheets of medium to large cells with abundant eosinophilic cytoplasm, uniform round nuclei, vesicular chromatin, and prominent nucleoli (Figure 2). Definitive Reinke crystals were not visualized and a Sertoli cell component was not seen. Overt features of malignancy (increased mitotic activity, nuclear atypia, hemorrhage, or necrosis) were not identified. The cells of interest were strongly and diffusely positive for markers of sex cord-stromal differentiation (calretinin and inhibin) and were negative for pancytokeratin and EMA (Figure 3). In addition to the grossly identified left ovarian mass, numerous microscopic nests and cords of identical-appearing cells were present in the right ovary and in additional sections from the left ovary (Figure 3). Hyperplasia of non-neoplastic hilus cells was identified within the left ovarian hilus. The constellation of pathologic findings in concert with the clinical features was consistent with the bilateral presentation of pure ovarian Leydig cell tumor.
From diagnosis to treatment of androgen-secreting ovarian tumors: a practical approach
Published in Gynecological Endocrinology, 2022
Patrycja Rojewska, Blazej Meczekalski, Grzegorz Bala, Stefano Luisi, Agnieszka Podfigurna
Steroid Cell Tumors (SCTs) represent less than 0.1% of all ovarian tumors. They differ from LCTs in that their composite cells do not feature Reinke crystals on histopathology. Most known instances of SCTs occur earlier in life than LCTs, with the average age at diagnosis being 43 years. More than 50% of diagnosed SCTs are androgen producing, but occasionally estrogens, cortisol, and progesterone producing variants have been observed [10].