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DRCOG MCQs for Circuit C Questions
Published in Una F. Coales, DRCOG: Practice MCQs and OSCEs: How to Pass First Time three Complete MCQ Practice Exams (180 MCQs) Three Complete OSCE Practice Papers (60 Questions) Detailed Answers and Tips, 2020
Ovarian tumours that secrete oestrogen include:Arrhenoblastoma.Dysgerminoma.Teratoma.Granulosa cell tumour.Thecoma.
Reproductive System and Mammary Gland
Published in Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, Chirukandath Gopinath, Page R. Bouchard, Toxicologic Pathology, 2018
Justin D. Vidal, Charles E. Wood, Karyn Colman, Katharine M. Whitney, Dianne M. Creasy
Lesions arising from sex cord–stromal elements are one of the most common types of proliferative changes observed in nonclinical species (Alison et al. 1987; Dixon et al. 1999; Lewis 1987). Stromal hyperplasia, with varying degrees of luteinization, is a commonly observed age-related change and can occur secondary to elevations in gonadotropins during anestrus or menopause. Tumors arising from sex cord-stroma often have distinct features and may be classified based on cell of origin. Subtypes include granulosa cell tumors, thecal cell tumors (thecoma), luteoma, and Sertoli cell tumors. Granulosa cell tumors are the most commonly observed primary ovarian tumor in rodents and have also been observed in dogs and NHPs (Alison et al. 1987; Cline et al. 2008; Dixon et al. 1999; Kennedy et al. 1994; Lewis 1987). Granulosa cell tumors can rarely be seen in bitches as young as 14 months and are observed on occasion as spontaneous ovarian tumors in toxicology studies (Figure 20.39) (McEntee 1990a). Approximately 80% of these tumors are benign (Dow 1960; Norris et al. 1970) and unilateral. In practice it may be difficult to distinguish these different subclassifications and a diagnosis of mixed sex cord–stromal tumor can be used.
Genitourinary, Adrenal, Obstetrics and Gynaecology and Breast
Published in Vincent Helyar, Aidan Shaw, The Final FRCR, 2017
Theses consist of thecoma, fibroma and fibrothecoma (most common). Usually large and benign, they look like fibroids, but on the ovary. Meig syndrome is a combination of fibroma, effusion and ascites, mimicking malignancy.
Luteinized thecoma (thecomatosis) with sclerosing peritonitis: a systematic review of the literature of the last 25 years
Published in Expert Review of Anticancer Therapy, 2021
Leonardo Muratori, Elena Trevisi, Marco Donatello Delcuratolo, Paola Sperone, Massimo Di Maio
Thecomas are rare neoplasms that represent between 1 and 2% of all ovarian tumors, according to different statistics [1,2]. These neoplasms arise from granulosa and theca cells and they can produce estrogens or, less often, androgens. Although this neoplasm can present as a very large abdominal mass, in most cases the oncological behavior is benign (less than 5% are malignant). Luteinized thecomas are a histological subtype, characterized by the presence of hormone-secreting cells similar to lutein cells and without crystalloids of Reinke, about 50% of cases with estrogenic expression and about 10% with androgenic expression [3]. Luteinized thecoma (thecomatosis) with sclerosing peritonitis (LTSP) is a very uncommon entity, representing an extremely rare subset of ovarian thecomas, with very few cases described in literature. This condition is characterized by the presence of a luteinized thecoma associated with an abnormal proliferation of fibroblasts in the peritoneum that results in an apparently irreversible fibrotic process, which incarcerates and strangles the abdominal organs. The natural history of the disease leads inexorably to bowel obstruction with fatal consequences. Today, knowledge and the expertise about this condition are very limited, because of its extreme rarity and the consequent small amount of publications and studies. Therefore, we realized a systematic review of literature, with the aim of collecting the data contained in the few articles available and take stock of current knowledge about LTSP and its possible strategies of management.
Ovarian Leydig cell tumour diagnosis in a postmenopausal woman with uterine bleeding: a case report and literature review
Published in Journal of Obstetrics and Gynaecology, 2022
Asuka Higuchi, Shunichiro Tsuji, Tsukuru Amano, Kyoko Kasahara, Fuminori Kimura, Takashi Murakami
Magnetic resonance imaging (MRI) revealed a 30-mm solid mass, low to medium intensity on a T2-weighted image, and low intensity on a T1-weighted image, in the right ovary. Radiological findings suggested hormone-producing tumours, such as fibroma or thecoma. Laboratory tests revealed marked increase in haemoglobin (Hb, 19.9 g/dL, normal range 11.6−14.8 g/dL), serum oestrogen (57.0 pg/mL, normal range approximately 42 pg/mL), and testosterone (5.8 ng/dL, normal range 0.11−0.47 ng/dL) levels. Erythropoietin levels were normal (10.1 mIU/mL, normal range 4.2−23.7 mIU/ml), and genetic screening for the JAK mutation was negative.
Adolescent ovarian thecoma presenting as progressive hyperandrogenism: case report and review of the literature
Published in Gynecological Endocrinology, 2020
Laura Gaspari, Françoise Paris, Patrice Taourel, Marie-Odile Soyer-Gobillard, Nicolas Kalfa, Charles Sultan
In conclusion, management of adolescent hirsutism/HA, which is frequent, remains a challenge. Its persistence some years after menarche should be investigated (basal plasma T, pelvic US). Although, ovarian thecoma is a rare neoplasm in adolescent, it should be included in the differential diagnosis. Even in absence of evidence for a direct impact of fetal environmental contamination by pesticides, the question of the possible association between ovarian tumors and prenatal exposure to endocrine disruptor chemicals may be discussed.