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Clinical Progresses in Regenerative Dentistry and Dental Tissue Engineering
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
Dental follicle is a loose vascular connective tissue composed of a heterogenous layer of an ectomesenchymal cells surrounding the enamel organ and the dental papilla of the developing tooth germ in early stages of tooth development prior to eruption (Lesot et al. 1993). This tissue contains progenitor cells that form the periodontium, i.e., cementum, PDL and alveolar bone. Precursor cells have been isolated from human dental follicles of impacted third molars. Recently, human dental follicle progenitor cells showed hard tissue-forming potential in immunocompromised rats (Yagyuu et al. 2010). Dental follicle stem cells may provide a cell source for tissue engineering. Similar to other dental stem cells, these cells form low numbers of adherent clonogenic colonies when released from the tissue following enzymatic digestion (Morsczeck et al. 2005).
Benign Oral and Dental Disease
Published in John C Watkinson, Raymond W Clarke, Terry M Jones, Vinidh Paleri, Nicholas White, Tim Woolford, Head & Neck Surgery Plastic Surgery, 2018
Konrad S. Staines, Alexander Crighton
The most common developmental odontogenic cyst is the dentigerous cyst (DC) and indeed is the most common cyst of the jaw in the paediatric age group. This cyst arises around the crown of an unerupted tooth with the wall of the cyst attached around the cervical margin of the involved tooth, with significant variation in size. DCs are more commonly unilocular but may also be a multilocular. Radiographically, a dental follicle-related radiolucency around an unerupted tooth should measure less than 4 mm from the surface of the tooth to the outer edge of the follicle; consequently any further increases should raise the possibility of cystic change. It is important to bear in mind that odontogenic tumours such as ameloblastoma and odontogenic keratocyst may involve unerupted teeth and present a diagnostic dilemma.
Oral cavity
Published in Paul Ong, Rachel Skittrall, Gastrointestinal Nursing, 2017
Alveolar bone develops from the dental follicle. This forms the sockets in which the teeth will sit. This can occur independently from the development of the tooth; however, to ensure that the tooth develops in the correct position the two processes must be coordinated. The tooth remains in the alveolar bone until eruption occurs. The gingival tissues (gum tissues) develop at this stage.
Dental stem cells for tooth regeneration: how far have we come and where next?
Published in Expert Opinion on Biological Therapy, 2023
The second branch of human dental mesodermal stem cells is a group of stem cells responsible for the development and the regeneration of the tooth attachment apparatus or periodontium, which is mainly made up of three types of dental tissues: the cementum, periodontal ligament (PDL), and alveolar bone, when the gingiva as fourth periodontal tissue is not taken into account. The PDL is an important connective tissue that provides a flexible connection between tooth and alveolar bone and contains multipotent stem cells (PDLSCs), which are an ideal source for the treatment of periodontitis and for other regenerative therapies of the tooth attachment apparatus [16,21,22]. Another source for stem cell-based periodontal treatments is dental follicle stem cells (DFSCs). The dental follicle like the apical papilla can only be obtained from impacted wisdom teeth. This embryonic-like tissue contains multipotent DFSCs, which are the genuine progenitors of the periodontium [22–25]. DFSCs have also been used successfully for tooth root regeneration approaches and should also have some potential for regenerative therapies of periodontitis. The next part of this article therefore looks at new developments in periodontal and tooth root regeneration.
Relevance of periodic evaluation of endodontically treated primary teeth
Published in Libyan Journal of Medicine, 2019
Sally Kamal El-Din Mohamed, Huda Abutayyem, Said Abdelnabi, Juma Alkhabuli
DC is commonly associated with mandibular 3rd mandibular molar [5]. However, in the current case, the cyst was associated with unerupted mandibular 2nd premolar. Although such cases are relatively uncommon, a few cases have been reported [6]. Shibata et al. [7] studied the occurrence of DC in association with succedaneous teeth during the transitional dentition phase and reported a prevalence of 77.1% in the premolar region. There have been several explanations for the development of inflammatory and non-inflammatory DC. Benn and Altini [8] suggested three pathways for histogenesis of DC. In the first scenario, the developmental DC arises from the dental follicle and becomes secondarily infected as a result of a non-vital tooth. The second form occurs when a permanent successor erupts into radicular cyst that forms at apex of a non-vital deciduous resulting into a DC that is extra follicular in origin. Nevertheless, a radicular cyst developing at apex of primary tooth is extremely rare. The third possible cause is due to spread of peri-apical inflammation from a non-vital deciduous tooth to a follicle of permanent successor.
Role of STRO-1 sorting of porcine dental germ stem cells in dental stem cell-mediated bone tissue engineering
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Gorke Gurel Pekozer, Mustafa Ramazanoglu, Karl Andreas Schlegel, Fatma Nese Kok, Gamze Torun Kose
Stem cells can be isolated from a variety of dental tissues including apical papilla of developing teeth (SCAP) and dental follicle (DFSCs). DFSCs and SCAP are generally cultured by dissecting dental follicle and apical papilla of immature tooth seperately. However, the use of whole tooth germ including dental follicle and its surrounding tissues is an alternative strategy which make use of reciprocal interactions between stem cells of ectoderm and mesoderm origin in order to preserve their stemness [11].