Gamma counter – Knowledge and References

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Translation of Radiopharmaceuticals

Published in Michael Ljungberg, Handbook of Nuclear Medicine and Molecular Imaging for Physicists, 2022

Pedro Fragoso Costa, Latifa Rbah-Vidal, An Aerts, Fijs W.B. van Leeuwen, Margret Schottelius

Most in-vivo and in-vitro sampling for radioactivity quantification (be it in form of autoradiography, gamma counter, SPECT, PET imaging) should be cross-calibrated to a reference dose calibrator. This will allow a more accurate assessment of interest metrics relevant for the radiopharmaceutical performance. In general terms, cross-calibration factors are nuclide-specific and will be valid for a specific range, provided by the manufacturer of the respective dose calibrator, in which signal response is linear. Animal imaging infrastructures are not bound by the same quality control requirements as human scanners, as such, there are many features that must be user-customized, requiring first line support that can be delivered by MPEs.

Evaluation of precorneal residence time of brimonidine tartrate nanoparticles loaded in situ gel using gamma scintigraphy

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Journal Information

Published in Inorganic and Nano-Metal Chemistry, 2020

Pankaj Kumar Sharma, Nidhi Sandal, Meenakshi Kanwar Chauhan

In vitro stability of radio-labeling was performed by mixing 100 μl of 99mTc-in situ gel with 900 μl of simulated tear fluid (pH 7.2) saline. The mixture was allowed to vortexing for proper mixing and kept at room temperature. All the radiolabeling activity was carried out in a hot lab under lead shielding. Small aliquots were withdrawn at different time intervals up to 24 h. In vitro stability of labeled formulation was evaluated by standard ITLC method by using acetone as a mobile phase. The radioactivity of samples was counted by a gamma counter.[31]