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Published in James G. Speight, Handbook of Petrochemical Processes, 2019
As stated previously, salicylic acid (or as a precursor to the acid), sodium salicylate is produced commercially by treating sodium phenate (the sodium salt of phenol—phenol is a well-known petrochemical starting material) with carbon dioxide at high pressure (1,500 psi) and high temperature (117°C, 242°F) (the Kolbe–Schmitt reaction) after which acidification of the product with sulfuric acid yield gives salicylic acid.
Synthesis and structural features of copper(II) complexes of N,N,N′,N′-tetramethylethylenediamine with 2-chlorobenzoate1− and 2-hydroxybenzoate1−
Published in Journal of Coordination Chemistry, 2018
Syeda Shahzadi Batool, Syeda Rubina Gilani, Muhammad Nawaz Tahir, William T. A. Harrison, Liviu Mitu, Sania Mazharr
Among biologically significant d-elements, copper is one of the essential micronutrients needed by all living organism and plays important roles in various biochemical processes [1]. Carboxylic acids constitute an important class of biologically important ligands. Benzoic acid, salicylic acid, and their derivatives such as acetylsalicylic acid and chlorobenzoic acids are among such biologically relevant carboxylic acids. Salicylic acid shows antioxidant, antiseptic, antibacterial, antifungal, keratolytic, and photoprotective activities and is used in skin ointments [2, 3].
Transesterification of methyl salicylate with isoamyl alcohol assisted by microwave irradiation and promoted by acid-basic catalysts
Published in Indian Chemical Engineer, 2023
Leandro Gutierrez, Pedro Mancini, María Kneeteman, Cristián Ferretti
The traditional method for salicylate synthesis is the esterification of salicylic acid with an alcohol in inorganic acid catalysts. This process has its thermodynamic reversibility and slow reaction rate. Thus, higher temperatures and longer reaction times must increase the performance. Concentrated mineral acid (as a catalyst) makes it harder to separate salicylate in the final production steps. Also, these catalysts are strongly corrosive, harmful to the environment, and not reusable [3].