China
Africa
Explore chapters and articles related to this topic
Screening and Pharmacological Management of Neuropathic Pain
Published in Suvardhan Kanchi, Rajasekhar Chokkareddy, Mashallah Rezakazemi, Smart Nanodevices for Point-of-Care Applications, 2022
Manu Sharma, Ranju Soni, Kakarla Raghava Reddy, Veera Sadhu, Raghavendra V. Kulkarni
Meprobamate, an anxiolytic drug, exhibits affinity to bind GABA receptors to pepper the neuronal transmission in the spinal cord. This symptomatically lessens pain sensation and produces sedation. Similarly, methocarbamol, a central muscle relaxant, is used to treat skeletal muscle spasms caused by musculoskeletal disorders, tetanus, and injury [42]. The GABA-derivative drug, baclofen, is mainly effective in managing muscle spasticity associated with spinal cord injury. Metaxalone is extensively used to relax muscle during strains, sprains, and other musculoskeletal conditions, although its mechanism of action is unclear [43]. Dantrolene is a hydantoin derivative. It produces muscle relaxation by dissociating excitation-contraction coupling possibly by restricting secretion of Ca+2 from sarcoplasmic reticulum by binding to ryanodine receptor1. It has been found suitable for the treatment of fulminant hypermetabolism of skeletal muscles [44].
Impact of intrauterine exposure to the insecticide coragen on the developmental and genetic toxicity in female albino rats
Published in Egyptian Journal of Basic and Applied Sciences, 2022
Amel Ramadan Omar, Ahmed Emam Dakrory, Marwa Mohamed Abdelaal, Heba Bassiony
Coragen as an insecticide that selectively targeting ryanodine receptors, a group of calcium ion channels found in cardiac and skeletal muscles. Nanomolar concentration of coragen locks the receptor in a half-open state, whereas its micromolar concentration fully closes them [35]. Furthermore, Abdel-Mobdy et al. [18] proved that coragen affects the calcium content in serum of rats given both sub-acute and sub-chronic doses, where a slight decrease in serum calcium content was observed in sub-acutely treated rats, and the highest decrease in serum calcium in the group received 1/2 of the LD50 that showed the most toxic effects.