Explore chapters and articles related to this topic
Rosmarinic Acid: A Boon in the Management of Cardiovascular Disease
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Md. Adil Shaharyar, Mahfoozur Rahman, Kumar Anand, Chowdhury Mobaswar Hossain, Imran Kazmi, Sanmoy Karmakar
Acute myocardial infarction (AMI) and arrhythmia are a menace to the society and a great cause of hospitalization and mortality respectively. The cellular calcium level is regulated by both Sarcoplasmic reticulum Ca2+ ATPase (SERCA2) and Ryanodine receptor (RyR2), respectively. The protocol was designed in such a way so as to investigate whether rosmarinic acid can safeguard cardiac functions against AMI and arrhythmia induced by Isoproterenol, modulated by both SERCA2 and RyR2 genotypically. For mechanism of rosmarinic acid in myocardial infarction refer to Figure 10.1 (Javidanpour et al., 2018).
Toxicity and effects on anuran tadpole metamorphosis of the anthranilic diamide insecticides chlorantraniliprole and cyantraniliprole
Published in Journal of Toxicology and Environmental Health, Part A, 2023
Shirley Vivian Daniela Fonseca Peña, Julie Céline Brodeur
Anthranilic diamides are a modern family of insecticides which are among the most widely marketed today in many countries (Hadiatullah et al. 2022; Zhang et al. 2022). The diamides act by binding to ryanodine receptors ion channels (RyR), leading to unregulated activation of muscle contraction (Samurkas et al. 2022; Selby, Lahm, and Stevenson 2016; Sun and Xu 2019). Target pest insects exhibit general lethargy, muscle paralysis and eventually death (Kimura et al. 2023; Lahm et al. 2005). Chlorantraniliprole (CHLO) is the first anthranilic diamide to have been registered in 2007 (Rezende-Teixeira et al. 2022). This insecticide is used to control Lepidoptera, Coleoptera and some Diptera at the larval stage mainly, as well as some adults (Bentley, Fletcher, and Woodward 2010; Hannig, Ziegler, and Marcon 2009) Diamides have residual properties and ingestion is their most effective mode of entry, although these insecticides might also enter the insect by contact (Bentley, Fletcher, and Woodward 2010). Cyantraniliprole (CYAN), is a second generation diamide insecticide that was registered in 2014 (European Food Safety Authority EFSA 2014) and was created to improve systemic properties in the plant (Barry et al. 2014; Selby et al. 2013). CYAN is active against a broad spectrum of sucking and chewing insects (Tiwari and Stelinski 2013).
Cardiac contractility modulation for the treatment of moderate to severe HF
Published in Expert Review of Medical Devices, 2021
Force production in the cardiac myocyte depends largely on calcium concentration in the cytosol of the cell. The process of contraction begins when a triggering amount of calcium enters the cell via the L-type calcium channel and triggers the ryanodine receptor on the sarcoplasmic reticulum (SR) to release its calcium content to the cytosol. It is this calcium that is responsible for facilitating actin-myosin cross-bridging, which leads to filament sliding and force production. Calcium must be removed from the cytosol to allow filament dissociation. Reuptake of calcium into the SR is facilitated by the protein SERCA2a.