Plant pharmacology: Insights into in-planta kinetic and dynamic processes of xenobiotics
Published in Critical Reviews in Environmental Science and Technology, 2022
Tomer Malchi, Sara Eyal, Henryk Czosnek, Moshe Shenker, Benny Chefetz
In addition to pharmacology, other fields of plant science could benefit from insight and understanding of the interactions of xenobiotic compounds and plants. Of specific relevance is pharmacognosy, i.e. the study of plants as producers of phytochemicals (primary and secondary metabolites). Secondary metabolites encompass a wide range of compounds (>200,000) and have been used for medicinal purposes throughout human history, while they continue to be the structural basis for many of the drugs we use today (Wink, 2010; Van Wyk & Wink, 2017). Furthermore, elicitors, i.e. exogenous compounds which induce or stimulate a defense response in plants for enhancement of secondary metabolite production, alter plant cellular activities at biochemical and molecular level and could provide even greater insight of the in-planta kinetic and dynamic processes. Understanding the biochemical processes, distribution, metabolism, accumulation and function of secondary metabolites and elicitors should be related to the study of plant pharmacology and provide mutual benefit, expanding our insight.