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Greener Synthesis of Potential Drugs
Published in Ahindra Nag, Greener Synthesis of Organic Compounds, Drugs and Natural Products, 2022
Renata Studzińska, Renata Kołodziejska, Daria Kupczyk
Five- and six-membered heterocycles containing nitrogen and oxygen atoms are also biological active compounds. Oxazoles and isoxazoles representatives show inter alia antimicrobial, anticancer, antitubercular, anti-inflammatory, and antidiabetic activity [85]. Oxazines derivatives additionally exhibit antioxidant and anti-osteoarthritis effects [86].
H3PW12O40 catalyzed new and multicomponent one-pot synthesis of 6-benzo[a]phenazin-5-ol derivatives of highly functionalized oxazoles via Robinson-Gabriel-type reaction
Published in Inorganic and Nano-Metal Chemistry, 2021
Mahdieh Hoseinpour, Razieh Mohebat, Mohammad Reza Nateghi, Forough Kalantari Fotooh
Oxazoles are useful five-membered heterocyclic compounds were commonly found in numerous natural products,[19] synthetic intermediates,[20] bioactive molecules,[21] pharmaceutical drugs,[22] advanced materials,[23] and ligand frameworks.[24] They have excessive variable properties with a highly diverse structures. Fully substituted oxazoles were also commonly found in numerous natural products and remarkably bioactive molecules such as Oxaprozin,[25] Diazonamide A,[26], and Siphonazole,[27] antidiabetic agent AD-5061,[28] and anti-inflammatory drugs aristoxazole,[29] contain 2,4,5-trisubstituted oxazole fragments attract great attention during the latest decade. By reason to their great importance a number of substantial strategies have emerged toward the synthesis of oxazoles and fully substituted oxazoles skeleton in recent years, for instance: (a) Robinson-Gabriel synthesis:[30] Synthesis of oxazole by dehydration of 2-acylaminoketones. (b) Formation of oxazole from condensation of cyanohydrin and aldehyde. (c) Synthesis of oxazole by the Bredereck reaction between α-haloketones and formamide. (d) Using the VanLeusen reaction gives oxazole by reacting with aldehyde and TosMIC.[31] (e) Cycloisomerization of certain propargyl amides is used to oxazole synthesis, A synthesis of novel benzoxazole under ultrasound irradiation[32] and Synthesis of novel derivatives of benzoxazole in bis-ionic liquid [BDBDIm] Br.[33]