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Microwave-Assisted Transition Metal-Catalyzed Synthesis of Pharmaceutically Important Heterocycles
Published in Banik Bimal Krishna, Bandyopadhyay Debasish, Advances in Microwave Chemistry, 2018
Dipti Shukla, Priyank Purohit, Asit K. Chakraborti
Indoles are important heterocycles in medicinal chemistry because of their abundance in several bio-relevant natural products and marketed drugs. Hence, the development of methodologies for the synthesis of indole derivatives with various substitution is of significant value to medicinal chemists. Muralidharan and co-workers synthesized substituted indoles using palladium catalyst under microwave heating [58]. The protocol involves the annulation reaction of ortho-iodo aniline 50 and aldehyde 51 to provide various substituted indole derivatives 52 with good to excellent yield (Scheme 9.20). To investigate the optimum condition, the authors tried different catalytic systems and PdCl2/A-taphos and CsOAc in dioxane under microwave irradiation was found to be the best condition.
N-Polyheterocycles
Published in Navjeet Kaur, Metals and Non-Metals, 2020
Fischer indole synthesis is the most important method for the preparation of substituted indole. Herein, phenylhydrazine reacts with pyruvic acid, followed by decarboxylation to synthesize an indole. This method follows a one-pot route under microwave irradiation (Scheme 56) [176].
Isolation of bacteria with plant growth-promoting properties from microalgae-bacterial flocs produced in high-rate oxidation ponds
Published in Environmental Technology, 2023
Wiya L. Masudi, Yinka Titilawo, Taobat A. Keshinro, A. Keith Cowan
To determine the ability of the isolated bacterial strains to produce indole-3-acetic acid (IAA), NB was supplemented with L-trp, and the concentration of indolic compounds was determined using Salkowski’s reagent [36–38]. To determine indole production potential, NB supplemented with L-trp (1 g.L−1) was used as a medium, inoculated with 0.05 mL of each isolated strain seed culture, and incubated for 3 d at 30°C. Thereafter, samples were centrifuged (18,900 × g for 10 min), and the concentration of indoles was quantified by adding two drops of 10 mM H3PO4 to 2 mL supernatant followed by 4 mL Salkowski reagent (prepared by adding 1.0 mL 0.5 M FeCl3 to 50 mL 35% HClO4) and expressed as IAA equivalents. The mixture was allowed to stand at room temperature for approximately 15 min. The quantity of indoles was determined spectrophotometrically at 530 nm, followed by interpolation from a standard curve of authentic IAA (Sigma-Aldrich) and background subtracted to account for any interference from the culture medium as described elsewhere [27].