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Oxide Nanoparticles in Heterogeneous Catalysis
Published in Varun Rawat, Anirban Das, Chandra Mohan Srivastava, Heterogeneous Catalysis in Organic Transformations, 2022
Garima Sachdeva, Jyoti Dhariwal, Monika Vats, Varun Rawat, Manish Srivastava, Anamika Srivastava
Pyrroles belong to an important class of heterocyclic compounds and are extensively used as bioactive molecules in alkaloids, co-enzymes, and porphyrins. Sabbaghan et al. reported the effective and eco-friendly method for synthesis of polysubstituted pyrroles via three-component reaction of amine, dialkyl acetylene dicarboxylates, and phenacyl bromide using ZnO-nanorod as catalyst under solvent-free conditions (Figure 2.6). Solvent-free conditions make the synthesis simple, efficient in terms of atom economy, and prevent solvent toxicity and hazards.
N-substituted Pyrroles by a Simple and Green Route
Published in Ahindra Nag, Greener Synthesis of Organic Compounds, Drugs and Natural Products, 2022
K. Arabpourian, Farahnaz K. Behbahani
Also, the pyrrole nucleus exists in various biological activities as analgesic5,6CNS depressant,7 antifungal,8 antimycobacterial,9,10 anticancer,11 anticonvulsant12,13 and anti-HIV14 activities. The most general approach for the synthesis of N-substituted pyrroles is the Paal–Knorr reaction15,16 in which 1,4-dicarbonyl compounds are resulted pyrroles using primary amines and 1,4-dicarbonyl compounds. Various methods for the synthesis of pyrrole derivatives have been developed such as FePO417 and other references cited therein. Herein, we wish to present a mild and green route for the Paal–Knorr synthesis of N-substituted pyrroles using 1,4-dicarbonyl compounds and amines using starch as a green, readily available and reusable catalyst (Scheme 11.1).
Thermal Nanosensors
Published in Vinod Kumar Khanna, Nanosensors, 2021
A porphyrin is any one of a class of water-soluble, nitrogenous biological pigments (biochromes), derivatives of which include the hemoproteins (porphyrins combined with metals and protein). A porphyrin is an organic compound that contains four pyrrole rings. A pyrrole is a pentagon-shaped ring of four carbon atoms with a nitrogen atom at one corner (C4H5N). The porphyrins are an enormous group of organic compounds, found all over the living world. They are universal, found in most living cells of animals and plants, where they perform a wide variety of functions. The special property of porphyrins is that they bind metals. The four nitrogen atoms in the middle of the porphyrin molecule act as teeth: they can grab and hold metal ions such as magnesium (Mg), iron (Fe), zinc (Zn), nickel (Ni), cobalt (Co), copper (Cu), and silver (Ag).
Synthesis of Fe3O4@L-proline@SO3H as a novel and reusable acidic magnetic nanocatalyst and its application for the synthesis of N-substituted pyrroles at room temperature under ultrasonic irradiation and without solvent
Published in Inorganic and Nano-Metal Chemistry, 2022
Fatemeh Shokri, Farahnaz K. Behbahani
One useful example of reusable and recyclable nano magnetic catalysts is Fe3O4@L-proline@SO3H, which has been prepared for first time and reported in this article for the preparation of N-substituted pyrroles. The pyrrole ring is part of various biologically active compounds that exhibit analgesic,[22,23] CNS depressant,[24] antifungal,[25] antimycobacterial,[26,27] anticancer,[28,29] anticonvulsant,[30,31] and anti-HIV activity.[32] A few syntheses of pyrrole derivatives have been reported[33] and the others references therein. The most common synthetic approach to N-substituted pyrroles is based on the Paal–Knorr reaction[34,35] of 1,4-dicarbonyl compounds with primary amines such as Fe(ClO4)3/SiO2.[36] In this communication, and ongoing our researches in the application of nano catalysts in the organic transformations,[37–40] we wish to report an efficient, mild, and green protocol of the Paal–Knorr synthesis of N-substituted pyrroles from 1,4-dicarbonyl compounds and amines in the presence of Fe3O4@L-proline@SO3H as a green and reusable catalyst (Scheme 1).
14N Nuclear quadrupole coupling and methyl internal rotation in the microwave spectrum of 2-methylpyrrole
Published in Molecular Physics, 2020
Thuy Nguyen, Christina Dindic, Wolfgang Stahl, Ha Vinh Lam Nguyen, Isabelle Kleiner
Pyrroles are nitrogen containing five-membered ring systems which possess unique organoleptic properties [6]. Some pyrroles are used as flavour additives. In the 1960s, pyrroles became known to represent a minor class of potentially significant flavour-associated compounds that occur naturally in foods. Pyrrole and the methyl substituted compound, 2-methylpyrrole (2MP), are found in volatile compounds from fried chicken [7]. Pyrrole also provides the key structural subunit for many of the most important biological molecules, such as heme and chlorophyll. Pyrrole and its derivatives exhibit a wide range of biological and pharmaceutical activities, i.a. antibacterial, anti-fungal, anti-viral, anti-inflammatory, anti-cancer and antioxidant activity [8].