Fischer indole synthesis

Fischer indole synthesis is a significant chemical process used to create substituted indole, which is considered the most crucial method for its preparation. It is one of several synthesis methods for indole and its derivatives, including cyclization of 2-alkynylaniline and reductive cyclizations of nitro compounds, that have been extensively studied.From: Metals and Non-Metals [2020], Ferrocenyl induced one-pot synthesis of 3,3′-ferrocenylbiindoles [2020]

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N-Polyheterocycles

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Published in Navjeet Kaur, Metals and Non-Metals, 2020

Navjeet Kaur

Fischer indole synthesis is the most important method for the preparation of substituted indole. Herein, phenylhydrazine reacts with pyruvic acid, followed by decarboxylation to synthesize an indole. This method follows a one-pot route under microwave irradiation (Scheme 56) [176].

Ferrocenyl induced one-pot synthesis of 3,3′-ferrocenylbiindoles

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Published in Journal of Coordination Chemistry, 2020

Ligang Yan, Limin Han, Ruijun Xie

The indole nucleus is a common substructure of many natural products and pharmaceutical compounds, found in calycanthidine, chimonanthine, psychotriasine, melatonin, and tryptophan [1–4]. Synthesis methods of indole and its derivatives, such as Fischer indole synthesis, cyclization of 2-alkynylaniline, and reductive cyclizations of nitro compounds [5], have been studied extensively. Transition metal-catalyzed C–H activation of indoles also played important roles for the synthesis of indole derivatives, for example, palladium-catalyzed electrophilic substitution reaction of indole and umpolung of 2-indolylmethanols can be used to construct a large number of indole derivatives [6–12].