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Conducting Polymer-Based Micro-Containers for Biomedical Applications
Published in Ram K. Gupta, Conducting Polymers, 2022
Selcan Karakuş, Cemal Özeroğlu, Mizan İbrahim Kahyaoğlu
5-Fluorouracil is an anticancer agent and nucleobase analogue and it inhibits DNA synthesis and slows tumor growth. Hsiao et al. fabricated the electrically conductive polypyrrole-tungsten disulfide nanocomposite with higher electrical conductivity and biocompatibility properties for in vivo 5-fluorouracil (5-FU) anticancer drug release in mice skin. The fabricated polypyrrole-tungsten disulfide nanocomposites were characterized by different techniques such as UV-Vis, XRD, Raman, and SEM techniques. The prepared polypyrrole-tungsten disulfide nanocomposites had an aggregated flake-like morphology. 5-FU-loaded nanocomposite had a high release (%) of 90% drug under electrical stimulation. The encapsulation efficiency of the synthesized polypyrrole-tungsten disulfide nanocomposites was found to be in the range of 36.58–56.91%. Also, the electrochemical results of nanomaterials showed that the synthesized conductive polypyrrole-tungsten disulfide nanocomposites had a high electroactive property and can be used as an effective and conductive nanocargo for drug release studies [34]. Chahm et al. prepared a novel electrochemical platform to detect oligonucleotides using polypyrroles due to conducting surfaces. Their results showed that the mechanism was based on the excellent organic conducting surfaces of polypyrroles [35].
Cross-Linked Polymers for Drug Delivery Systems
Published in Munmaya K. Mishra, Applications of Encapsulation and Controlled Release, 2019
Wu et al. developed in situ gels from phospholipids and medium-chain triglycerides for the delivery of DOX [80]. In vivo studies revealed a significant antitumor effect of the formulation on S180 sarcoma tumor-bearing mice after a single administration of the formulation intratumorally. The in vivo biodistribution study showed a high DOX concentration in the tumors when compared with other major organs after intratumoral administration. The high concentration of DOX in the tumor and long-term retention revealed that in situ gels are a promising drug delivery system for chemotherapy [80]. Luo et al. developed a phospholipids-based in situ-forming gel for the co-delivery of DOX and bromotetrandrin. The release of DOX and bromotetrandrin from the phospholipid gel was sustained in vitro for over 3 weeks. The release of both drugs was prolonged for 2 weeks in vivo in rats that were administered the formulation via subcutaneous injection. The formulation did not induce cardiac toxicity when administered in rats via subcutaneous injection. A single administration of the formulation by intratumoral injection in the resistant MCF-7/Adr xenograft–bearing mice further showed good antitumor efficacy by reversing the multidrug resistance in breast cancers [81]. Yang et al. reported phospholipids-based in situ gels for intratumoral injection. which can enhance the antitumor and antimetastasis effect simultaneously [82]. The gel was co-loaded with 5-fluorouracil and magnesium oxide, and intratumoral administration in 4T1-bearing mice resulted in extended survival time and significant antitumor and antimetastasis effect when compared with the free drug [82]. Kwon et al. reported combinational chemotherapy via intratumoral injection of DOX and 5-fluorouracil to reduce the toxic effects of systemically administered DOX and 5-fluorouracil. The formulations were injected intratumorally in mice, and the formulation containing both drugs inhibited the tumor growth significantly when compared with the formulation containing a single drug. The in vivo biodistribution showed high concentrations of both drugs in the target tumor, suggesting that concentrations below the drug’s toxic plasma concentration would not result in systemic toxicity [83].
Drug delivery systems of CoFe2O4/chitosan and MnFe2O4/chitosan magnetic composites
Published in Preparative Biochemistry & Biotechnology, 2022
Ayşegül Yildirim, Yasemin Ispirli Doğaç
Within the scope of the study, these two different magnetic materials were used as drug carriers to create the synergistic effect of the magnetic hyperthermia-cancer drug. In the study, 5-Fluorouracil (5-FU), an important drug used in cancer chemotherapy in colon, rectum, breast, stomach, pancreas, bladder, cervix, head and neck, liver, ovarian, prostate, and skin cancers, was selected as a model cancer drug. It was observed that two different carrier types (CFC and MFC) prepared were able to keep the amount of active substance released in accordance with the models used for controlled drug systems.