Developing Taxanes for Oral Intake Employing Apt Nanocarriers
Published in Bhupinder Singh, Om Prakash Katare, Eliana B. Souto, NanoAgroceuticals & NanoPhytoChemicals, 2018
Rajneet Kaur Khurana, Teenu Sharma, Harpreet Kaur, Anchal, Kaisar Raza, Bhupinder Singh
Despite the potential promises, the challenges associated with the oral taxane delivery vouch significant attention. The oral absorption of these agents is hampered by the co-administered of drugs, food items, nutritional supplements, and herbal medications, which may unpredictably influence bioavailability (Khurana et al., 2016). On the other hand, side effects—such as dysphagia, nausea, odynophagia, gastrectomy, vomiting, and diarrhea—generally associated with oral administration are the other major concern. Therefore, the regimen needs to be supplemented with antiulcer and antiemetic drugs prior to oral chemotherapy.