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Product: Alfa-Tox
Published in Charles R. Foden, Jack L. Weddell, First Responder’s Guide to Agricultural Chemical Accidents, 2018
Charles R. Foden, Jack L. Weddell
HEALTH HAZARD INFORMATION: No specific medical conditions are known that may be aggravated by exposure to the active ingredient in this product. However, pulmonary and respiratory diseases may be aggravated by exposure to crystalline silica, a component of this formulation.A physician should be contacted if anyone develops any signs or symptoms and suspects that they are caused by exposure to this product.
Pharmaceuticals
Published in James G. Speight, Handbook of Petrochemical Processes, 2019
Petrochemicals play an important role in the production of medicines. For example, most medicines contain two types of ingredients: (i) the active ingredient which is composed of one or more compounds manufactured synthetically or extracted and purified from plant or animal sources and the active ingredient is the chemical that reacts with your body to produce a therapeutic effect and (ii) the inactive ingredients which are typically the additives present in the medication which are normally inactive/inert and which may have been added as preservatives, flavoring agents, coloring, sweeteners, and sorbents.
Preparation of allantoin loaded liposome formulations and application for cosmetic textile production
Published in The Journal of The Textile Institute, 2025
Güneş Sayıt, Sakine Tuncay Tanrıverdi, Özgen Özer, Esen Özdoğan
Loading capacity (LC) and encapsulation efficiency (EE) of formulations was determined by centrifuge method (Mura et al., 2007). The suitability of centrifugation method for determination of encapsulation efficiency had been demonstrated by Mura et al. (2007) and Lopez-Pinto et al. (2005). Liposome suspension was centrifuged at 14,000 rpm for 30 min. Supernatant and precipitate were separated. Samples from supernatant were analyzed with UPLC method. Precipitate was diluted with ethanol to destroy liposome vesicles and then suspension was centrifuged at 14,000 rpm for 30 min. The amount of drug was measured from the supernatant by UPLC method. The encapsulation efficiency was determined by dividing of active ingredient found practically with theoretically loaded active ingredient using allantoin calibration curve. And then the percentage was calculated for EE%. Loading capacity (LC) was determined by dividing percentage amount of active substances to total amount of solid ingredients.
Application of a three-fluid nozzle for the preparation of amorphous solid dispersions
Published in Drying Technology, 2023
Carolina Corell, Stefan Seyferth, Dagmar Fischer, Heiko A. Schiffter
To determine whether ASDs can be prepared using a three-fluid nozzle and whether the samples are comparable to those obtained by spray drying with a two-fluid nozzle, individual solutions of carbamazepine and copovidone or basic butylated methacrylate copolymer (abbreviated E PO) in methanol were prepared. For the experiments with the two-fluid nozzle, the active ingredient together with the polymer excipient were dissolved in methanol. In the first set of experiments using the three-fluid nozzle, the drug solution was sprayed through the inner capillary and the polymer solution was sprayed through the outer capillary. Three different API:polymer mass ratios (1:3, 1:1, and 3:1) were prepared. The process parameters for each experiment are listed in Table 1. The inlet temperature, solvent, and overall liquid feed rate were kept constant in all experiments to achieve the best possible comparability between the spray-dried products obtained with the two different nozzle types. The physicochemical properties of all samples produced were characterized subsequently.
Astaxanthin encapsulation in nanocapsule by high-pressure homogenization technology: a study on stability, antioxidant activity and in vitro release
Published in Journal of Dispersion Science and Technology, 2023
Liyuan Gu, Suping Ji, Bi Wu, Wenjuan Wang, Jingfang Cheng, Qiang Xia
Lipid nanocapsules (LNC) are lipid-based nano-carriers, which have been fully tested and show advantages in the delivery of active substances.[17] LNC is considered to have structural arrangement hybridization between liposomes and polymer nanoparticles.[18] They are composed of an oily core surrounded by a shell made of solid lipids and emulsifiers.[19] The active ingredient was encapsulated in the LNC.[20] The primary advantages of LNCs are biodegradability and biocompatibility, which can improve the bioavailability of active substances.[21] However, the astaxanthin-related carriers were prepared in the prior art, astaxanthin oil is generally dissolved in organic solvents, such as acetone.[22] The residual organic solvent after the reaction is not friendly to the environment and will cause some environmental pollution. Therefore, the development of an astaxanthin nano-carrier with high efficiency, low toxicity, low dosage, and low environmental pollution has become an urgent technical problem. The preparation process of this study selects food-grade materials with safety and little environmental pollution to produce astaxanthin nanocapsules, which can be used in food and health products.