Toxicogenomics

Toxicogenomics

Toxicogenomics is the study of the toxic effects of chemicals, including drugs and other compounds, with the goal of understanding the mechanisms of toxicity and predicting the toxicity of unknown substances. It involves the use of genomic and proteomic tools to investigate the activity of genes and proteins in response to toxic substances, providing mechanistic insights into toxicity assessment and complementing the hazard identification process.From: Biomarkers of Environmentally Associated Disease [2019], Advances in Food Biochemistry [2019], p-synephrine induces transcriptional changes via the cAMP/PKA pathway but not cytotoxicity or mutagenicity in human gastrointestinal cells [2021], Applied Molecular Biotechnology [2019]

Glossary of scientific and technical terms in bioengineering and biological engineering

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Published in Megh R. Goyal, Scientific and Technical Terms in Bioengineering and Biological Engineering, 2018

Megh R. Goyal

Toxicogenomics is a fusion of genomics and toxicology disciplines intended to identify, classify and manage the latent (inherent susceptibility), incipient and overt adverse (toxic) effects on genome structure and expression levels (RNA, protein, cell/tissue/organ type) as a consequence of an organism’s exposure to environmental substances (contaminants such as chemicals, drugs and micro/multicellular organisms and/or components) and stressors (for example, quality of air, climate, soil, solar radiation and water).

p-synephrine induces transcriptional changes via the cAMP/PKA pathway but not cytotoxicity or mutagenicity in human gastrointestinal cells

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Published in Journal of Toxicology and Environmental Health, Part A, 2021

Diego Luis Ribeiro, Ana Rita Thomazela Machado, Carla Machado, Alexandre Ferro Aissa, Patrick Wellington Dos Santos, Gustavo Rafael Mazzaron Barcelos, Lusânia Maria Greggi Antunes

Various investigators demonstrated that toxicogenomic tools provide mechanistic insights into toxicity assessment and complement the hazard identification process (Krewski et al. 2010; Krewski et al. 2020). It remains unclear the molecular effects that SN exerts in human cells and which biological signaling pathways it modulates. Analysis of the chemical structure and pharmacological action of SN indicates that its molecular action resembles that of its analogs via interference on the cAMP/PKA (3′,5′-cyclic adenosine monophosphate/protein kinase A) signaling pathway (Faubert et al. 2015; Schmitz-Spanke 2019; Wu et al. 2018).

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Glossary of scientific and technical terms in bioengineering and biological engineering

p-synephrine induces transcriptional changes via the cAMP/PKA pathway but not cytotoxicity or mutagenicity in human gastrointestinal cells