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Engineering Bone Formation with Biologically Inspired Nanomaterials
Published in Iniewski Krzysztof, Integrated Microsystems, 2017
The collagenous phase plays a central role in the regulation of mineralization, control of cell division, migration, differentiation, and maturation, and maintenance of matrix integrity, growth factor modulation, and the extent of mineral–collagen interactions [54,55]. Noncollagenous proteins play complex functions during bone formation and remodeling [56]. The collagenous phase facilitates communication with the cellular environment and provides a medium for proteins to maintain their bioactivity [57,58]. For example, osteonectin protein is involved in several functions including linking of the mineral and collagenous phases and regulation of mineralization. An engineered composite should mimic the complexity of the bone’s extracellular matrix with nanoscale structures to control cell–matrix interactions.
Bioinspired Nanomaterials for Bone Regeneration
Published in Šeila Selimovic, Nanopatterning and Nanoscale Devices for Biological Applications, 2017
The collagenous phase plays a central role in the regulation of mineralization; the control of cell division, migration, differentiation, and maturation; the maintenance of matrix integrity; growth factor modulation; and the extent of mineral–collagen interactions [45,46]. Noncollagenous proteins play complex functions during bone formation and remodeling [47]. The collagenous phase facilitates communication with the cellular environment and provides a medium for proteins to maintain their bioactivity [48]. For example, osteonectin (ON) protein is involved in several functions including linking the mineral and collagenous phases and regulating mineralization. An engineered composite should mimic the complexity of the bone ECM with nanoscale structures to control cell–matrix interactions.
Reduction and Fixation of Sacroiliac joint Dislocation by the Combined Use of S1 Pedicle Screws and an Iliac Rod
Published in Kai-Uwe Lewandrowski, Donald L. Wise, Debra J. Trantolo, Michael J. Yaszemski, Augustus A. White, Advances in Spinal Fusion, 2003
Kai-Uwe Lewandrowski, Donald L. Wise, Debra J. Trantolo, Michael J. Yaszemski, Augustus A. White
Osteoblasts are bone-building cells and are responsible for bone formation, maintenance, and degradation through their influence on osteoclast function. They are mesenchymal stem cells (MSC) derivatives and proceed through a number of osteoblastic iterations throughout their lifecycle. This cycle begins after the MSC is exposed to the appropriate environmental cues, both chemical and mechanical, and starts to express various preosteoblast characteristics. This includes expression of nuclear transcription factors such as core binding factor alpha 1 (CBFA1), protein production to include alkaline phosphatase and collagen type I (col I), and responsiveness to growth factors and cytokines such as prostaglandin (PGE2), epidermal growth factor (EGF), and transforming growth factor (31 (TGF-(31) [1-3]. Determination of the osteoblast phenotype by morphology alone is near impossible; therefore, functional classification based on extracellular matrix (ECM) is preferred. As the osteoblast matures, protein production alters and the ECM develops into mature bone matrix with the addition of osteopontin, osteonectin, and osteocalcin, all of which are important for mineralization of the osteoid either in the development or in the ossifying callus of the spinal fusion site. Osteoclasts
Carbon-based nanomaterials as scaffolds in bone regeneration
Published in Particulate Science and Technology, 2020
Liana Crisan, Bogdan Vasile Crisan, Simion Bran, Florin Onisor, Gabriel Armencea, Sergiu Vacaras, Ondine Patricia Lucaciu, Ileana Mitre, Mihaela Baciut, Grigore Baciut, Cristian Dinu
Osteopontin (OP), a non-collagenic phosphoprotein contains in its structure GDR tripeptide, characteristic of adhesion molecules, tripeptide which can be found in the structure of fibronectin and fibrinogen, vitronectin, osteonectin, suggesting the involvement of osteopontin in cell–cell adhesion phenomenon–cell, cell–extracellular matrix respectively taking place during cell proliferation and migration (Yamate et al. 1997).