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Utilization of Fisheries' By-Products for Functional Foods
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Muhamad Darmawan, Nurrahmi Dewi Fajarningsih, Sihono, Hari Eko Irianto
A diet of fish collagen hydrolysates may be useful in controlling the temporal increase of plasma triglycerides. The in vivo studies showed that metabolism and lipid absorption in rats were affected by the diet with fish skin collagen hydrolysates. Plasma triglycerides of rats were reported to be decreased significantly by fish collagen peptide 2 h after the intake (Saito et al., 2009). Clinical investigations have also reported that the pain of patients suffering from osteoarthritis was reduced by the intake of collagen/gelatin hydrolysate. The synthesis of cartilage matrix, which is used as a gene delivery promoting bone agent, also involves hydrolyzed collagen (Moskowitz, 2000; Nakagawa and Tagawa, 2000)
Dentin-Pulp Complex Regeneration
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
Amaury Pozos-Guillén, Héctor Flores
Collagen is a major protein that can be found in sinew, cartilage, bone and skin. One of the most important advantages of collagen is that it can be processed into a variety of set-ups, as porous sponges, gels and sheets, and can also be crosslinked with chemicals to make it stronger or to alter its degradation rate (Nasir et al. 2006). Collagen sponges have demonstrated to be similar to the structure of an extracellular matrix, they have low immunogenicity and cytotoxicity, and also, the ability of forming several shapes and stimulating the differentiation of osteoblasts (Silver and Pins 1991; Chevallay et al. 2000). Collagen sponge scaffolds and gels have been reported for tooth regeneration; results suggest that not only does collagen retain and support cell proliferation and differentiation, but also help in the production of calcified tissues (Sumita et al. 2006). Seeding Dental Pulp Stem Cells (DPSC) on a collagen scaffold, the collagen scaffold could stimulate a systematized comparable matrix formation similar to that of pulp tissue (Prescott et al. 2008). Collagen scaffold allows easy placement of cells and growth factors. It also allows for substitution by natural tissues after suffering degradation (Sumita et al. 2006; Yamauchi et al. 2011). However, the results are not always consistent; consequently, the characteristics of collagen scaffolds and gels require further investigation before being applied in human trials.
Pharmaceutical Applications of Collagen
Published in Amit Kumar Nayak, Md Saquib Hasnain, Dilipkumar Pal, Natural Polymers for Pharmaceutical Applications, 2019
K. Sangeetha, A. V. Jisha Kumari, E. Radha, P. N. Sudha
The presence of collagen was an important form of protein in skin, and as we grow older, the body naturally stops the amount of collagen production which results in wrinkling, facial sagging and rough appearance in the skin. To maintain collagen level stable throughout our life was practically not possible, but we can slow down the effect of aging by taking plenty of nutrients to increase the production of collagen in the body. Collagen supplement will enhance skin elasticity, boost the hydration of the skin, and prevents the damage caused by ultraviolet light.
The hemostatic effect and wound healing of novel collagen-containing polyester dressing
Published in Journal of Biomaterials Science, Polymer Edition, 2023
Collagen can be cross-linked to the chemical to change the rate of degradation, and is a common biological wound dressing and hemostatic dressing. Collagen is not only absorbed by the human body, but has biological compatibility, low immune response, low antigen, non-toxic, and is often used to treat chronic wounds, such as burns, pressure sores, leg ulcers, and bedsore ulcers [11]. Collagen is a significant component of the extracellular matrix (ECM), which sustains the structural integrity of biological and extracellular matrix ECM, mainly in bones, skin, cartilage, ligaments, and tendons [12]. Fibrous collagen used in tissue engineering [13] can be processed into various forms, such as porous sponges, gels [14], sheets (flat, granular, etc.), Electropunk for facile and straight forward form [15], and nanoparticles [16].
Dietary supplements for consideration in elite female footballers
Published in European Journal of Sport Science, 2022
Hannah C. Sheridan, Lloyd J. F. Parker, Kelly M. Hammond
Musculoskeletal injuries are the most common injury type in athlete populations with the incidence of soft tissue injury reaching up to 60% in players from the EPL (Baar, 2017). This is of particular significance to female athlete populations whereby ACL injury is 4–6 times more likely compared with male athletes (Hewett, Myer, Ford, Paterno, & Quatman, 2016). Collagen is a key component of musculoskeletal connective tissues (tendons, ligaments, cartilage and bone), the structure and function of which depends on the abundance of collagen in the extracellular matrix (Baar, 2017; Shaw, Lee-Barthel, Ross, Wang, & Baar, 2017). Since collagen protein makes up more than 80% of tendons and ligaments, research over the last decade has investigated the value of collagen supplementation in joint pain, injury rehabilitation and injury prevention for athletes. Indeed, a study in 97 athletes who had previously suffered with joint pain demonstrated that supplementation with collagen hydrolysate over a 24-week period significantly reduced joint pain both at rest and while running and changing direction (Clark et al., 2008). In addition, recent data demonstrate that when combined with loading on the joint, supplementation with 15 g of vitamin C enriched gelatine (a product rich in collagen) 1-h prior to intermittent activity significantly improved collagen synthesis in comparison to 5 g or a placebo (Shaw et al., 2017).
Extraction, anti-tyrosinase, and antioxidant activities of the collagen hydrolysate derived from Rhopilema hispidum
Published in Preparative Biochemistry & Biotechnology, 2021
Noor Atikah Ab Aziz, Norazlinaliza Salim, Mohammad Zarei, Nazamid Saari, Fatimah Md. Yusoff
Collagen is the most abundant structural protein in human and animal bodies. In human, collagen make up more than 30% of total protein, which account 75% of the dry weight of skin.[1] Collagen can be mainly found in all connective tissues, including skin, bone, tendon, and cartilage.[2] Collagen has been a crucial biomaterial used in different industries, extended from sausage making in food sector to drug delivery in biomedical sector.[3] However, the source of collagen is mainly from bovine and porcine. Safety issue of bovine collagen has been raised over last decades due to the outbreak of disease known as bovine spongiform encephalopathy (BSE) that can be transmitted to human, leading to development for alternative.[4,5] On the other hand, the use of pig’s collagen poses religious issues particularly among Muslims and Jewish. Therefore, collagen derived from marine organism like edible, local jellyfish is preferred to solve these issues.