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Production of Life-Saving Drugs from Marine Sources
Published in Prasenjit Mondal, Ajay K. Dalai, Sustainable Utilization of Natural Resources, 2017
Enfumafungin (56), an acidic triterpenoid isolated from the fungus Hormonema, showed antifungal activity by inhibiting 1,3-β-D-glucan synthase (Lamoth and Alexander 2015). A semisynthetic derivative of enfumafungin SCY-07876 (57; MK-3118) is in clinical trials against fungal infections (Pfaller et al. 2013). Another important cyclic cationic antifungal peptide NP213 (58; Novexatin®), a derived analog of natural cationic peptides with seven arginine residues (Li and Breaker 2012), is being developed by Nova Biotics Ltd. Clinical studies have established Novexatin as safe, well-tolerated and effective agent for the treatment of onychomycosis (nail infections).
Fungal bioaerosol as an occupational hazard in the podiatrist’s workplace
Published in International Journal of Environmental Health Research, 2023
Beatriz Alija-Martínez, Ricardo Becerro de Bengoa Vallejo, David Sevillano Fernández, Natalia González, Marta Elena Losa Iglesias, Luis Collado, Rubén Espinosa-Rubio, Luis Alou
T. rubrum was the most frequent dermatophyte, isolated in 6 of the 8 positive samples (75%). This finding is in agreement with numerous publications that report T. rubrum as the most frequently isolated dermatophyte in onychomycosis and Tinea pedis (Seyfarth et al. 2007) and has been linked to allergic reactions in susceptible people (Woodfolk 2005). Several studies have reported the presence of T. rubrum antibodies in the serum of participating podiatrists (Abramson and Wilton 1992b; McLarnon 2000). Likewise, this is the most prevalent genus isolated in the analysis of the dust contained in the vacuum bags of podiatric air suction systems, originated by the electric burr reduction of fungal infected nails and skin (Abramson and Wilton 1992a; Hainsworth et al. 2015).
Erythrocyte morphology and fatigue levels in podologists
Published in International Journal of Environmental Health Research, 2022
Burcu Yuksel, Serap Arsal Yildirim, Fikriye Polat
Along with the data on respiratory tract diseases, the risk of exposure to fungi in podiatry professions seems to be high, but especially onychomycosis is the most common nail disease affecting 5.5% of the world’s population (Gupta and Quinlan 2021). Podologists trained to recognize and treat onychomycosis can be exposed to many types of fungi, including dermatophytes (86%), Aspergillus species (spp.), Candida, Scopulariopsis spp, Trichophyton rubrum, and non-dermatophyte mold (Hainsworth et al. 2015). However, researchers have reported that fungal exposure sources can also come from normal-looking nails and feet (Nowicka et al. 2016). The addition of fungi to inhaled dust, which can reach deep into the lungs, further increases the risk to workers’ health (Woodfolk 2005). While most healthy people can endure inhaled fungi, they can react with inflammatory Type 2 T helper cells, causing excessive mucus production, bronchoconstriction, and in severe cases, lung tissue damage (Boonpiyathad et al. 2019). While most healthy, immune-competent podologists do not experience respiratory ailments, those who are prone to allergies or have weakened immune systems experience respiratory diseases due to fungi on the skin, nails, and inhalation of chemical elements (Gupta and Quinlan 2021).
Synthesis, characterisation and electrochemical evaluation of a functionalised coating for mild steel corrosion protection
Published in Surface Engineering, 2019
Victoria Bustos-Terrones, Jorge Uruchurtu, Jesús J. Rochín-Medina, Karina Ramírez, Jesús G. Rangel-Peraza, Mario A. Romero-Romo, Yaneth Bustos-Terrones
Fluconazole (F) is an antifungal triazol type used in the treatment of cryptococcosis, hysto-plasmosis [29], and in the prophylaxis of infections where other anti-fungals have failed or have been not tolerated by the patient, including candidiasis, onychomycosis and cryptococcal meningitis [30].