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Solid-Lipid Hybrid Nanostructures and Their Biomedical Applications
Published in Surender Kumar Sharma, Nanohybrids in Environmental & Biomedical Applications, 2019
Kanwal Akhtar, Yasir Javed, Hafeez Anwar, Khuram Ali, Naveed A. Shad
Topical administration: Tremendous use of SLN due to the attractive characteristics of colloidal systems is suitable because of low toxic and non-irritant lipids for many skin applications. Topically applied lipid hybrid nanoparticles showed enhanced efficacy of UV molecular blockers with minimum side effects, increased hydration, drug release modifications, wrinkle smoothing, reduced pigment effect and protection from various chemical compounds. In many cases, incorporation of SLN dispersions in gel/ointment can be necessary to for topical administration. Jain et al. (2010) reported that miconazole nitrate formulation possessed enhanced retention in hydrogel of SLNs as compared to miconazole nitrate hydrogel and miconazole nitrate suspensions (Jain et al., 2010). They performed in vivo studies on infected rats with candida species. They observed that for treatment of candidiasis, miconazole nitrate-loaded hydrogel of SLNs were more efficient. SLN formulations with active compounds such as clotrimazole (Souto et al., 2004), retinol (Jenning et al., 2000), triptolide (Mei et al., 2003), ascorbyl palmitate, tocopherol acetate (Wissing and Müller, 2001), nonsteroidal antiandrogen RU 58841 and phodphyllotoxin (Chen et al., 2006b) for topical applications have been studied from the last few years.
Convenient synthesis of N-sulfonyl α-hydroxyamides via DMSO oxidation of N-alk-1-ynylsulfonamides
Published in Journal of Sulfur Chemistry, 2023
Jiayi Wang, Dongning Sheng, Duo Fu, Jiaxi Xu
α-Hydroxyamides are the crucial structural motifs in some bioactive molecules and also have been widely used as synthetic intermediates [1]. Many medicine molecules containing α-hydroxyamide fragments exhibit anticancer activities and analgesic effect [2,3]. For example, bicalutamide has been used in the treatment of the prostate cancer [4]. Hydroxyflutamide is a nonsteroidal antiandrogen drug [5]. Iopamidol is applied as a nonionic iodized contrast agent for cardiovascular disease clinically in the medical imaging [6]. Naproanilide has been utilized as herbicides in agriculture [7] (Figure 1). In organic synthetic chemistry, α-hydroxyamides have been utilized as the protective groups in the total synthesis of cyclotheonamide A [8], and synthetic intermediates for the preparation of α-substituted amides through acylation with acetic anhydride and deacetoxylative alkylation [9].