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Conducting Polymer-Based Nanomaterials for Tissue Engineering
Published in Ram K. Gupta, Conducting Polymers, 2022
Murugan Prasathkumar, Chenthamara Dhrisya, Salim Anisha, Robert Becky, Subramaniam Sadhasivam
The neurotrophic factors like nerve growth factor (NGF), neurotrophin-3 (NT-3), BDNF, ciliary neurotrophic factor (CNTF), FGF, TGF-β, and glial-derived neurotrophic factor (GDNF) are commonly involved in neural regeneration. Encapsulating the growth factors/therapeutic drugs on the conductive scaffolds can stabilize the controlled release of the drug for constructive regeneration of the nerve cells. The PLGA/dextran/hyaluronic acid scaffold is a classic example of the encapsulation and delivery of BDNF at the site of spinal cord injury. The developed hydrogel showed excellent electrical conductivity mimicking the natural spinal cord and exhibited a stable release of BDNF. Moreover, histological results demonstrated the neural differentiation to neurons and inhibitory effects on astrocytes differentiation as astrocytes contribute to the prevention of axonal regeneration during injury [41]. Likewise, injectable gelatin/PANI-based hydrogels with bone marrow stromal cells (BMSCs) could act as a drug delivery system for Parkinson's disease. It also improved the expression of tyrosine hydroxylase positive (TH+) dopaminergic neurons, BDNF, and GDNF [42]. In this way, electroactive materials transmit the electrical cues to the neural tissue and improve the regenerative process.
Correlation of BDNF and cognitive function in smoking Batak male schizophrenic patients
Published in Cut Adeya Adella, Stem Cell Oncology, 2018
E. Effendy, M.M. Amin, N. Utami, F.H. Sitepu
Over two decades of research has highlighted the relationship of cognitive performance with the neurotrophins system. Neurotrophins are a unique family of polypeptide growth factors with similar structures that are involved in the process of brain development, differentiation and survival of neurons, synaptic plasticity, and connectivity. The neurotrophins comprise of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) (Bath et al., 2006). BDNF, a member of the neurotrophic family, is common in the mammalian brain and plays an important role in the development, regeneration, survival, maintenance, and function of the neuron (Zhang et al., 2015; Niitsu et al., 2011). BDNF is a protein highly involved in the development of the nervous system of all mammals, and in the regulation of synaptic transmission. During the period of development, BDNF has been involved in the survival of stem cells, neurogenesis, and neuronal differentiation along with polarisation and neuronal guidance. BNDF also regulates the plasticity aspect of the brain and is thus involved in cognitive function (Rowbotham et al., 2015).
Magnetic Nanoparticles for Neural Engineering
Published in Nguyễn T. K. Thanh, Clinical Applications of Magnetic Nanoparticles, 2018
Gerardo F. Goya, Vittoria Raffa
Based on the concepts of magnetofection, i.e. the use of magnetic forces on MNPs to improve transfection efficiency, therapeutic approaches against NDs have begun to use magnetically labelled viral units to deliver genetic material. The construction of magnetic viral vectors (usually adenovirus or lentivirus) for a magnetic field-assisted viral transduction has been reported for some years now. This technique is known as magnetotransduction, and is often related (but not restricted) to strategies for delivering neuroprotective molecules to target cells as a therapy against ND diseases. One of the main goals of this approach is related to the enhancement in the levels of neurotrophic factors delivered, since it is accepted that an increase in the delivered concentration of these factors can prevent neural degeneration and enhance recovery of remaining neuron neuroprotective molecules at the target site.98
Acute exercise increases BDNF serum levels in patients with Parkinson’s disease regardless of depression or fatigue
Published in European Journal of Sport Science, 2022
Lílian Viana dos Santos Azevedo, Jéssica Ramos Pereira, Renata Maria Silva Santos, Natalia Pessoa Rocha, Antônio Lúcio Teixeira, Paulo Pereira Christo, Victor Rodrigues Santos, Paula Luciana Scalzo
The brain-derived neurotrophic factor (BDNF), a member of the neurotrophins family, is critically important for specific processes, including neuron survival, the growth and differentiation of dendrites and axons, the regulation of synaptogenesis, and synaptic plasticity (Adachi, Numakawa, Richards, Nakajima, & Kunugi, 2014; He, Zhang, Yung, Zhu, & Wang, 2013). In central motor structures, BDNF may also improve dopaminergic neurotransmission and activate anti-apoptotic signaling cascades that enhance the survival of dopaminergic neurons (Adachi et al., 2014; He et al., 2013).