Nephrotic syndrome

Lupus Nephritis

Published in Richard K. Burt, Alberto M. Marmont, Stem Cell Therapy for Autoimmune Disease, 2019

Focal proliferative lupus nephritis, which is present in 10-20% of cases, represents a more advanced form than class II. By definition, less than 50% of glomeruli are affected on light microscopy. There are segmental areas of hypercellular lesions with proliferation of glomerular cells and occasional necrosis. On EM, there are immune deposits in the subendothelial space and in the mesangium. Almost all patients have hematuria and proteinuria with some exhibiting nephrotic syndrome, hypertension and decreased renal function.

Coordination polymers constructed from 5-nitro-1,2,3-benzenetricarboxylic acid: crystal structures and treatment effect on nephrotic syndrome by regulating intestinal flora and recovering Th17/Treg balances

View Article

Journal Information

Published in Inorganic and Nano-Metal Chemistry, 2020

Tingting Qiu, Xin Yi, Lulu Xu, Lifeng Wang, Xihui Hu, Xiaozhong Li

Nephrotic syndrome (NS) is a group of clinical syndromes in which the permeability of the glomerular basement membrane is increased by a variety of causes, resulting in the loss of large amounts of protein from the plasma through the urine.[1,2] NS is a common chronic kidney disease and a major primary disease that could induce the production of renal failure. The etiology and pathogenesis of nephrotic syndrome are complex and involve many factors such as infection, autoimmunity, drugs, genetics, and the environment. The etiology and pathogenesis of NS are still unclear.[3] Although glucocorticoids and immunosuppressive agents can alleviate the symptoms, the side effects and the high recurrence rate limit its application, which may eventually develop into chronic glomerular sclerosis.

Nephrotic syndrome

Explore chapters and articles related to this topic

Lupus Nephritis

Coordination polymers constructed from 5-nitro-1,2,3-benzenetricarboxylic acid: crystal structures and treatment effect on nephrotic syndrome by regulating intestinal flora and recovering Th17/Treg balances