China
Africa
Explore chapters and articles related to this topic
Aegle marmelos
Published in Cristobal N. Aguilar, Suresh C. Ameta, A. K. Haghi, Green Chemistry and Biodiversity, 2019
Hema Joshi, Rajeev Singh, Anamika Singh
Diuretic is a drug that increases the output of urine. This drug is usually given to individuals with increased water retention. Research has found that roots and leaves of bael have natural diuretic activity and it increases the passage of urine. Scientific studies have found that treatment with bael leaves and roots enhanced urine volume and increased the excretion of electrolytes such as sodium and potassium. They work by decreasing the re-absorption of sodium and fluid in the body. Studies even found that diuretic activity of bael roots was higher than that of leaves. Such an activity of bael makes it important in the treatment of congestive heart failure, kidney failure, and high blood pressure where water retention is common.
Antihypertensive Drugs: Controlling Blood Pressure
Published in Richard J. Sundberg, The Chemical Century, 2017
A second group of diuretics, including furosemide, bumetamide, and torsemide, is called “loop diuretics.” The first of these compounds, furosemide, was discovered when it was tested in a search for carbonic anhydrase inhibitors. These compounds have very rapid diuretic and natriuretic activity. The locus of action is a region of the kidney where little readsorption takes place. The loop diuretics also have vasodilation effects. The loop diuretics are also used in treatment of acute pulmonary and renal edema and in congestive heart failure.
Patient condition-based medicine inventory management in healthcare systems
Published in IISE Transactions on Healthcare Systems Engineering, 2019
Initially, the number of individual patient records collected from the hospital central pharmacy was 745,176 records. After removing the pharmacy items other than medicines, such as examination gloves, syringes, etc., the number reduced to 215,935 records. From these records, around 619 records of a selected medicine were obtained and used for this study. The selected medicine is furosemide 2 ml injections, a diuretic given to patients admitted to the hospital and suffering from heart failure. The basis for selection of this medicine is that it is prescribed mostly in the hospital under study and has been difficult to control due to high variability and uncertainty in its demand pattern. The five stages of treatment of patients with heart failure are shown in Fig. 5, where the diuretic medication is required in treatment stage “C” and “C and D with preserved EF.”
Using molecular dynamics simulations to identify the key factors responsible for chiral recognition by an amino acid-based molecular micelle
Published in Journal of Dispersion Science and Technology, 2019
Kevin F. Morris, Eugene J. Billiot, Fereshteh H. Billiot, Jordan A. Ingle, Kevin B. Krause, Corbin R. Lewis, Kenny B. Lipkowitz, William M. Southerland, Yayin Fang
The ligands investigated in this study were alprenolol, propranolol, 1,1′-bi-2-naphthyl-2,2′-diyl hydrogen phosphate (BNP), 1,1′-bi-2-naphthol (BOH), chlorthalidone, and lorazepam. The structures of these compounds are shown in Figure 1b–1g. The binding of alprenolol, propranolol, BOH, and BNP enantiomers to poly(SULL) have been investigated experimentally by Billiot et al.[22] Propranolol and alprenolol are β-blocker drugs and chlorthalidone is a thiazide diuretic used to treat fluid retention in patients with hypertension.[29] BNP and BOH are used in chiral syntheses[30,31] and their interactions with amino acid-based MM have been studied by a variety of experimental techniques.[32–37] Finally, lorazepam is a benzodiazepine drug used to treat anxiety, insomnia, and seizures.[38] By investigating the association of these structurally diverse chiral compounds with poly(SULL), the MM binding sites with the most favorable ligand: MM intermolecular interactions were identified along with the factors determining which of a chiral compound’s enantiomers had the lower MM binding-free energy. The insight gained will then be used in subsequent work to build the quantitative predictive models discussed above.
Preparation and characterization of solid lipid nanoparticles of furosemide using quality by design
Published in Particulate Science and Technology, 2018
Hasan Ali, Sandeep Kumar Singh
On the basis of research findings from the literature, we selected Furosemide (FRSM) as the potential drug candidate of choice for the fabrication of SLN (Figure 1). FRSM is approved as a diuretic for the treatment of hypertension and edema, caused by renal impairment and cardiac dysfunction (Granero et al. 2010). It is the anthranilic acid derivative and acts as a loop diuretic, available in the market as Lasix® (Wu and Benet 2005; Granero et al. 2010). The FRSM is a BCS class IV category drug candidate. It shows low aqueous and pH-dependent solubility, low permeability and variable intersubject bioavailability (Shin and Kim 2003; Wu and Benet 2005; Granero et al. 2010).