Loop diuretics

Loop diuretics

Antihypertensive Drugs: Controlling Blood Pressure

Published in Richard J. Sundberg, The Chemical Century, 2017

A second group of diuretics, including furosemide, bumetamide, and torsemide, is called “loop diuretics.” The first of these compounds, furosemide, was discovered when it was tested in a search for carbonic anhydrase inhibitors. These compounds have very rapid diuretic and natriuretic activity. The locus of action is a region of the kidney where little readsorption takes place. The loop diuretics also have vasodilation effects. The loop diuretics are also used in treatment of acute pulmonary and renal edema and in congestive heart failure.

Preparation and characterization of solid lipid nanoparticles of furosemide using quality by design

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Journal Information

Published in Particulate Science and Technology, 2018

Hasan Ali, Sandeep Kumar Singh

On the basis of research findings from the literature, we selected Furosemide (FRSM) as the potential drug candidate of choice for the fabrication of SLN (Figure 1). FRSM is approved as a diuretic for the treatment of hypertension and edema, caused by renal impairment and cardiac dysfunction (Granero et al. 2010). It is the anthranilic acid derivative and acts as a loop diuretic, available in the market as Lasix® (Wu and Benet 2005; Granero et al. 2010). The FRSM is a BCS class IV category drug candidate. It shows low aqueous and pH-dependent solubility, low permeability and variable intersubject bioavailability (Shin and Kim 2003; Wu and Benet 2005; Granero et al. 2010).

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Antihypertensive Drugs: Controlling Blood Pressure

Preparation and characterization of solid lipid nanoparticles of furosemide using quality by design