China
Africa
Explore chapters and articles related to this topic
Nanoparticulate Systems for Lung Cancer Targeted Therapy
Published in Devarajan Thangadurai, Saher Islam, Jeyabalan Sangeetha, Natália Cruz-Martins, Biogenic Nanomaterials, 2023
Ana Cláudia Pimenta, Luísa Nascimento, Natália Cruz-Martins
Surgical treatment is used with curative intent, mostly for NSCLC in its early stages, due to its limited role in SCLC (Nasim et al., 2019). It targets the complete resection of the tumor, along with its regional lymph nodes, allowing the correct tumor staging and determining the post-surgical treatment (Nasim et al., 2019). Even for small lesions, lobectomy is usually necessary to obtain R0 resection (disease free margins) owing to the tumor’s growth characteristics; wedge resections are associated with higher local recurrence (Lemjabbar-Alaoui et al., 2016; Nasim et al., 2019). Regrettably, lobectomy is only suitable for patients with an estimated postoperative predicted FEV1 >40% or VO2 max of at least 15 mL/kg/min, criteria that are often not met, due to impaired lung function related to tobacco smoke (Nasim et al., 2019). For stages II and III, even for patients electable for surgery, there is also a need for adjuvant or neoadjuvant chemotherapy (Table 7.1) (Lemjabbar-Alaoui et al., 2016).
Lung Cancer Screening Using Low-Dose Computed Tomography
Published in Ayman El-Baz, Jasjit S. Suri, Lung Imaging and CADx, 2019
Alison Wenholz, Ikenna Okereke
Minimally invasive thoracic surgery is beneficial to patients because it decreases postoperative pain for the patient. Performing the surgery thoracoscopically or with robotic assistance minimizes surgical incisions and reduces trauma to tissues. This results in shorter hospital stays, reduced blood loss, decreased pain, and less scarring. Since the late 1990s, video-assisted thoracic surgery (VATS) has been utilized, particularly for early-stage lung cancers. One study analyzed the perioperative parameters in patients who underwent lobectomy by either an open approach or a VATS approach, and the consensus was that VATS major lung resection is favorable and results in shorter hospital stay and reduced overall costs [22]. According to a retrospective, multi-institutional database analyses of nearly 4,000 patients who underwent either open lobectomy or VATS lobectomy, VATS lobectomy was significantly superior to an open approach in hospital costs, length of stay, and risk of adverse events [22]. The only disadvantage of VATS procedure is a longer operating time, but recently most centers that have active minimally invasive programs have experienced similar operative times as the surgeon experience level has increased. Minimally invasive thoracic surgery is the optimal choice for patients undergoing a lobectomy if technically possible.
Emerging Trends in Nanotechnology for Diagnosis and Therapy of Lung Cancer
Published in Alok Dhawan, Sanjay Singh, Ashutosh Kumar, Rishi Shanker, Nanobiotechnology, 2018
Nanda Rohra, Manish Gore, Sathish Dyawanapelly, Mahesh Tambe, Ankit Gautam, Meghna Suvarna, Ratnesh Jain, Prajakta Dandekar
Tumors in the early stages I and II of non–small cell lung cancer (NSCLC) can be successfully removed surgically by anatomic segmentectomy, wedge resection, lobectomy, or pneumonectomy (Lang-Lazdunski 2013). These techniques are described below.
Computational modelling of airflow in distal airways using hybrid lung model
Published in Mathematical and Computer Modelling of Dynamical Systems, 2023
Olusegun J. Ilegbusi, Adnan Islam, Anand P. Santhanam
The geometric features of the distal airways are affected by excessive deposition of cells, mucous or airway remodelling due to immune response. The hybrid lung model developed in this study may be readily adapted for detailed analysis of flow in the distal airway generations as well as regional flow distribution by employing the relevant pathological conditions. It can be used for lobectomy planning. Lobectomy is the partial or full removal of lung lobes that is often utilized as surgical treatment for subjects with lung disease including cancer and diseases inherited due to genetic predisposition or smoking habits [41]. The methodology developed in this study isolates lobes by application of lobe-specific boundary conditions for detailed analysis. It is thus ideally suitable for future analysis of such pathological situations.