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Lysosomal Storage Disorders and Enzyme Replacement Therapy
Published in Peter Grunwald, Pharmaceutical Biocatalysis, 2020
Niemann-Pick disease, Fabry disease, Krabbe disease, Gaucher disease, Tay-Sachs disease and metachromatic leukodystrophy (MLD), and Faber and Sandhoff disease are members of this group of diseases. As the name suggests, they are all related to the sphingolipid metabolism. Sphingolipids (or glycosylceramides) play important roles in cell recognition and signaling pathways based on their ability to interact with cell surface proteins (lectins, receptor proteins, etc.), as summarized in an excellent review by Wennekes et al. (2009). Recent studies have elucidated the enormous complexity they contribute to the lipidome (the totality of lipids in cells) and its many functions in health and disease (Hannun et al., 2018).
Physical activity and lipidomics in a population at high risk of type 2 diabetes mellitus
Published in Journal of Sports Sciences, 2020
Joseph Henson, Charlotte L. Edwardson, Melanie J. Davies, Jason M.R. Gill, Liam M. Heaney, Kamlesh Khunti, Leong Ng, Naveed Sattar, Francesco Zaccardi, Thomas Yates
However, there has been limited research on lipidomics and physical activity in populations at high risk of chronic disease. This is an important limitation as international recommendations and policies specify that chronic disease prevention strategies should include targeted interventions aimed at the identification and management of high-risk individuals (Chatterton et al., 2012; Paulweber et al., 2010). Therefore, the importance of sedentary behaviour and physical activity in this group needs to be better understood in order to inform the content and structure of prevention programmes. Moreover, previous investigations have typically categorised sedentary behaviour and physical activity (light, moderate, vigorous) using population-dependent thresholds. Using a broader continuum of intensity categories allows for greater insight into the dose–response relationship between physical activity intensity and health outcomes (Jelleyman et al., 2017). This is important as previous research has typically focused on MVPA, which occupies a very small fraction of the day, if at all. Conversely, substantial cardiometabolic benefits may be gained from light‐intensity activity, particularly in those at high risk of chronic disease (Chastin et al., 2019), which may also represent a more feasible means to increasing overall activity volume. Applying this approach to measurements of the lipidome may allow for greater understanding of how lipid metabolism differs across the precise physical activity intensity spectrum.
Assessment of the effects of repeated doses of potassium iodide intake during pregnancy on male and female rat offspring using metabolomics and lipidomics
Published in Journal of Toxicology and Environmental Health, Part A, 2019
Clément Rosique, Dalila Lebsir, Philippe Lestaevel, Sheherazade Benatia, Pierre Guigon, François Caire-Maurisier, Marc Benderitter, Djawed Bennouna, Maâmar Souidi, Jean-Charles Martin
It was of interest to examine whether some parts of the KI-sensitive metabolome or lipidome correlated to these behavioral tests results. In females, 2 of 6 of the functional sets in the KI-sensitive metabolome were markedly correlated with FST outcomes: amino acid and tyrosine metabolism (Figure 6(b)). In the lipidome (Figure 6(c)), 3 of 6 of KI-sensitive lipid clusters were correlated to FST outcomes: DHA-bearing lipids, lipolytic products, and ether lipids. In males, 3 of 9 of the metabolic functional sets were correlated to RRT motor coordination outcomes: amino acid metabolism, metabolic disorder, and cell signaling (Figure 7(b)). In the lipidome, 4 of 6 of KI-sensitive lipid clusters were correlated to RRT: lipolytic products, acyl phospholipids, triglycerides, and DHA-bearing lipids (Figure 7(c)).