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Thermal Imaging for Inflammatory Arthritis Evaluation
Published in U. Snekhalatha, K. Palani Thanaraj, Kurt Ammer, Artificial Intelligence-Based Infrared Thermal Image Processing and Its Applications, 2023
U. Snekhalatha, K. Palani Thanaraj, Kurt Ammer
Thermal imaging is a non-contact, non-invasive, diagnostic imaging procedure based on skin temperature measurement. It is a functional imaging method for analyzing physiological functions related to body temperature. It has been used as a pre-screening tool in various clinical applications of rheumatology, such as diagnosis of patellofemoral arthralgia in knee joint (Devereaux et al., 1986), monitoring of skin temperature elevations in scleroderma (Maeda et al., 1998), rheumatoid arthritis (RA), (Devereaux et al., 1985), knee osteoarthritis (Warashina et al., 2002), and juvenile idiopathic arthritis (Spalding et al., 2008).
Current Use and Future Promise of Genetic Engineering
Published in Michael Hehenberger, Zhi Xia, Huanming Yang, Our Animal Connection, 2020
Michael Hehenberger, Zhi Xia, Huanming Yang
Humira (Adalimumab) has been approved for rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, moderate to severe chronic psoriasis and juvenile idiopathic arthritis. Adalimumab was the first fully human monoclonal antibody drug approved by the FDA and is still one of the most prescribed drugs.
Mobilization and Conditioning Regimens in Stem Cell Transplant for Autoimmune Diseases
Published in Richard K. Burt, Alberto M. Marmont, Stem Cell Therapy for Autoimmune Disease, 2019
For malignancies, autologous HSCT is generally appropriate if the disease is chemotherapy responsive. The concept is to dose escalate disease responsive drugs to myeloablation, followed by rescue with autologous hematopoietic stem cells (HSC). Cancers nonresponsive to chemotherapy, such as pancreatic cancer or squamous cell lung cancer, would not be appropriate for consideration of autologous HSCT. Similarly, autoimmune diseases that are responsive to immunosuppressive therapy appear to be responsive to dose escalation and autologous HSCT. Examples of immune responsive diseases are: systemic lupus erythematosus (SLE), Crohn’s disease (CD), pemphigus vulgaris (PV), relapsing-polychondritis, relapsing-remitting multiple sclerosis (RRMS), rheumatoid arthritis (RA), and juvenile idiopathic arthritis (JRA). Response does not seem to be dependent on cytokine profile, since SLE and Crohn’s disease that are Th2 and Th1 skewed, respectively, seem to respond equally well.28-30
Meaningful involvement of children and young people in health technology development
Published in Journal of Medical Engineering & Technology, 2022
Gemma Wheeler, Nathaniel Mills, Ursula Ankeny, Philippa Howsley, Clare Bartlett, Heather Elphick, Paul Dimitri
Juvenile Idiopathic Arthritis (JIA) is an autoimmune disease that causes inflammation of the joints [32] with 1,000–1,500 new diagnoses in the UK each year [33]. JIA can affect CYP of all ages with experiences of the condition varying significantly, however key symptoms include ongoing pain and stiffness, making everyday activities difficult to achieve. Self-management activities to alleviate symptoms of JIA do exist, but they are currently not engaging for CYP. As such, a key unmet need for supporting CYP with JIA in the self-management of their condition was identified: using technology that can adapt to this plurality of experience.