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The Potential of Medicinal Plants with Anti-Proteus Activity for the Treatment (and Prevention) of Rheumatoid Arthritis
Published in Kailas L. Wasewar, Sumita Neti Rao, Sustainable Engineering, Energy, and the Environment, 2022
Alefiyah S. Bohra, S. R. Gupta, A. P. Kopulwar
Rheumatoid arthritis (RA) is an autoimmune disease that is characterized by inflammation at various synovial joints, which is evident by joint swelling, stiffness, deformity, and extreme pain [4]. Morning stiffness which is the symptom of other types of arthritis called osteoarthritis, it wears off within 30 minutes of getting up, but this lasts longer in RA patients. The exact cause of this disease is still unknown; however, the immune system is known to conciliate the progression of synovial diseased joints in RA [2]. RA is an autoimmune disorder, which means our immune system attacks its own healthy cells. In this case, synovial cells are auto immunized resulting in the synovial membrane swelling, hence promotes various causes. The most involved joints in RA are the MCP and PIP joints of the hands, wrists, and MTP joints of the feet [5]. Inflammation and following destruction in synovial joints are kinds of hallmark of RA. It involves interaction between T and B cells, macrophages, mast cells, plasma cells, synovial fibroblasts, and dendritic cells. The cell-to-cell interaction is either directly through cell-cell contact or via cytokines, such as TNFα, IL-1, and IL-6.
Thermal Comfort and Gender, Age, Geographical Location and for People with Disabilities
Published in Ken Parsons, Human Thermal Comfort, 2019
Rheumatoid arthritis is a long-term condition that causes pain, swelling and stiffness in the joints. The symptoms usually affect the hands, feet and wrists. It is often considered to be exacerbated by cold, high humidity and causes a high internal body temperature (fever) and sweating.
Advances in surgery of the hip joint in rheumatoid arthritis in adults
Published in K. Mohan Iyer, Hip Joint in Adults: Advances and Developments, 2018
There is no cure for rheumatoid arthritis (RA). The aetiology remains unknown, though there are several initiating factors seen with evidence of immune overactivity. However, certain aetiological factors may be involved, and the American Rheumatism Association has laid down certain criteria. The details are mentioned in my book entitled General Principles of Orthopedic and Trauma [1].
Serum substance P level as a marker for subclinical rheumatoid arthritis activity
Published in Egyptian Journal of Basic and Applied Sciences, 2023
Shimaa Borham Mohamed, Mohammed Fouad Elkenawy, Tamer Omar Elsaid, Ghada El-Saeed Mashaly
Rheumatoid arthritis is an autoimmune, multisystemic inflammation disease that causes substantial functional decline over time, radiographic damage, recurrent job incapacity, and early mortality [22]. Assessment of the illness’s activity is crucial for the best management of RA since rheumatoid flares and activity are linked to disease progression [23,24]. The primary goal of novel therapy approaches for RA, which include the currently available synthetic and biological DMARDs, is remission or at least low disease activity [25]. Remission, however, may not always signify a total absence of inflammation. Power Doppler ultrasound is one of the more sensitive instruments that is needed to assess the course of the disease [26]. These methods can be used to identify patients who are at risk of structural progression despite an apparent clinical response or to help with drug withdrawal decisions [20]. Inflammatory and immunological modulators like Substance P are one of the tools that have been suggested [14]. Inflammation, apoptosis, and the production of chemokines and pro-inflammatory cytokines are all significant aspects of how substance P controls the immune system [7].
Advancements of next generation sequencing in the field of Rheumatoid Arthritis
Published in Egyptian Journal of Basic and Applied Sciences, 2023
Ankita Pati, Dattatreya Kar, Jyoti Ranjan Parida, Ananya Kuanar
Rheumatoid arthritis (RA) is perceived to be a chronic disorder that has no cure till date. However, irrespective of the progressive nature of the disorder, the harm can be slowed down or prevented from getting worse by using disease-modifying drugs. Moreover, to attain the mentioned purpose, it is important to diagnose the diseases in early stages, as the amount of harm having occurred to the patient cannot be reversed. The medical experts have advocated four major stages for Rheumatoid arthritis (Figure 1).