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Biomedical Applications of Nanoscale Metal- Organic Frameworks
Published in Feng Chen, Weibo Cai, Hybrid Nanomaterials, 2017
Gasotransmitters are endogenously produced and critical signaling molecules in biological systems, which can easily diffuse through membranes without the help of a membrane receptor. Due to their extremely short life- time in blood, only a few sec, these gasotransmitters would only cause local effects upon being released, reducing the possibility of unwanted side effects (Horcajada et al. 2012). There are several advantages of using MOFs to deliver gasotransmitters over other materials, such as the absence of significant by- products from the storage and delivery process, possibility of highly controlled release and feasible formulation procedure to produce desired form of administration (cream, thin films, pellets, et. al) (Horcajada et al. 2012).
Physiological and pathophysiological implications of hydrogen sulfide: a persuasion to change the fate of the dangerous molecule
Published in Journal of the Chinese Advanced Materials Society, 2018
Jan Mohammad Mir, Ram Charitra Maurya
The scientific community was thrilled when the final outcome of the puzzling endothelium-derived relaxing factor (EDRF), a vasorelaxant substance synthesized and secreted from endothelial cells, was a gaseous molecule.[43] The conclusion that NO is an endogenous gaseous molecule, termed gasotransmitter, triggered the exploration of other possible gasotransmitters, including CO and H2S.[28] With the advent of these small signaling gasotransmitters a new type of science related to endogenously derived gases could elicit crucial biological functions, as well as contribute to the pathogenesis of human diseases.[44] Several other gases are currently under investigation to determine if they too act as endogenous mediators, including acetaldehyde, sulfur dioxide, dinitrogen oxide and ammonia. Overall, these new insights have improved our understanding of biological essence of gasotransmitters not only in physiological functions, but also in the pathogenesis of human diseases.