China
Africa
Explore chapters and articles related to this topic
*
Published in Valerio Voliani, Nanomaterials and Neoplasms, 2021
Eun-Kyung Lim, Taekhoon Kim, Soonmyung Paik, Seungjoo Haam, Yong-Min Huh, Kwangyeol Lee
Mulder et al. reported that PEGylated paramagnetic and fluorescent Gd–diethylenetriaminepentaacetic acid (DTPA)–bis(sterylamide) immunoliposome are capable of detecting E-selectin expression level [322]. E-selectin, endothelial cell surface receptor, is important to pathophysiological and therapeutic responses, including αvβ3-integrins and the VEGF receptor. Liposome particles could specifically bind to E-selectin overexpressing HUVEC cells, and cell internalization was confirmed by enhanced T1-weighted MRI signal. This system was particularly useful for detection of atherosclerosis, angiogenesis, and inflammation. Polymer-based theranostic nanoparticle systems utilizing MRI T1 imaging modality have been reported by several groups. Kataoka et al. formulated core–shell micelles in which Gd–DTPA and 1,2-diaminocyclohexane–Pt(II) were incorporated as the imaging agent and therapeutic agent, respectively [323]. Meade and Nguyen et al. prepared Gd(III)-conjugated polymer to load the drug gemcitabine [324].
Pullulan: Properties and Applications
Published in Shakeel Ahmed, Aisverya Soundararajan, Pullulan, 2020
Showkat Ali Ganie, Tariq Ahmad Mir, Akbar Ali, Qing Li
CHP nanoparticles modified by amine result into greater efficiency in vivo and in vitro as an anticancer drug carrier (docetaxel) for targeting cancer cells in lungs [125]. Both in vivo and in vitro, CHP-coated liposomes also have great liver-targeting capabilities [126]. The safe delivery from hydrophobically modified CMP nanoparticles to tumor cells occurs via hydrazone bonds with drugs. Antioxidant properties of CMP have strong attraction toward spleen and lymph nodes [127]. PH-sensitive CMP nanoparticles possess property of liver targeting and show well-behavior on different PH [128, 129]. CMP–drug conjugation leads to longer blood circulation of the drug, greater retention in tumor cells, having low cardiotoxicity with no hemolysis [130]. CMP can combine to treat autoimmune diseases with immune suppressants [131]. By adding jeffamines, thermosensitive CMP nanoparticles are created [132]. These nanoparticles are amphiphilic in nature and may maintain acidic, hydrophobic, and fundamental drugs for regulated applications in drug delivery [133]. CMP-Sialyl Lewis X complex can be used to treat various human illnesses (graft rejection, atherosclerosis, ischemia, asthma, etc.). It can readily interact with the expression of the cell-binding molecule E-selectin at inflammatory locations, which enables the delivery of cell-specific drugs in the receptor mediated.
Aptamer–Liposome Conjugates: Current Art and Future Prospects
Published in Rakesh N. Veedu, Aptamers, 2017
In a study toward the targeting of multiple cancer types Mann et al. in 2011 linked a thiolated aptamer against E-selectin to fluorescein-encapsulating liposomes [54]. Since E-selectin is selectively expressed by inflamed endothelial cells (e.g., in advanced tumors), this would enable a site-specific delivery of encapsulated therapeutics or contrast agents [55–59]. Earlier the same group described the development of a partly thiolated aptamer (ESTA) which was specific against E-selectin with a binding affinity of Kd = 47 nM [60]. ESTA was further 5′-modified with a Cy3 dye and a C10-linker bearing a carboxylic acid functionality (ESTA-Cy3) for coupling to prior extruded liposomes (DPPC/cholesterol/DSPE-PEG2000-NH2 58.9:40:1.1, molar ratio) modified with an amino poly(ethylene glycol) lipid. The liposomes were empty (L) or encapsulating a fluorescein dye (LFITC) for fluorescence studies. Aptamer–liposome conjugates (ESTA-LFITC) had a diameter of 119 nm, while bearing approx. 485 aptamers per liposome on the surface.
Folate receptor-specific cell-cell adhesion by using a folate-modified peptide-based anchor
Published in Journal of Biomaterials Science, Polymer Edition, 2019
Hiroko Nagai, Wataru Hatanaka, Masayoshi Matsuda, Akihiro Kishimura, Yoshiki Katayama, Takeshi Mori
In conclusion, we designed folate-modified peptide-based anchor to apply to the FRα-specific cell-cell adhesion. The peptide was modified on the K562 cell membrane in the presence of methyl ß-CD without cytotoxicity. The half-life time of the peptide on the cells was 4.1 hours and the peptide could be represented via recycling endosome. The peptide-modified cells successfully adhered to FRα-expressing KB cells and the adhesion was maintained at least 4 hours. The peptide-based anchor reported here would be applicable to present a variety of ligands. One of the promising applications of this peptide-based anchor will be an E-selectin binding peptide which will enable to deliver therapeutic cells to inflammation site [13].