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Mechanisms of Different Anticancer Drugs
Published in Anjana Pandey, Saumya Srivastava, Recent Advances in Cancer Diagnostics and Therapy, 2022
Anjana Pandey, Saumya Srivastava
Actinomycin D: Actinomycin D was first isolated and used for clinical use in 1954. It has a very broad spectrum of anticancerous activity. It is broadly used as a drug for the treatment of gestational trophoblastic tumors, tumors of germ cells, and Wilms’s tumors. The mode of action involves the binding of actinomycin D with dsDNA and inhibition of RNA synthesis (Li et al., 2018). Its specificity is determined by its penetration and ability to retain inside the tissues. It is not metabolized widely.
Paclitaxel and etoposide-loaded Poly (lactic-co-glycolic acid) microspheres fabricated by coaxial electrospraying for dual drug delivery
Published in Journal of Biomaterials Science, Polymer Edition, 2018
Mei Zhang, Yajun Tang, Zhenhua Zhu, He Zhao, Jihang Yao, Dahui Sun
Osteosarcoma (OS) is one malignant connective tissue tumor, the incidence of osteosarcoma takes the first position among the malignant tumor. Osteosarcoma is a common, high malignant degree and poor prognosis entity of the malignant osseous tumor. It’s spread to the lungs in a few months. The survival rate is only 5 to 20% after amputation 3 to 5 years. Local resection or resection of the tumor and chemotherapy may be used in the treatment of low grade osteosarcoma and peripheral sarcoma. If the tumor is highly malignant, preoperative chemotherapy plus amputation and postoperative chemotherapy should be adopted. The completion of the operation is not the end of the treatment, patients should adhere to the doctor's advice, insist on regular chemotherapy, in order to have a good prognosis. Significant progress have been made in the OS treatment in the preoperative chemotherapy with cisplatin (DDP), adriamycin (ADR), methotrexate-tetrahydrofolic acid (MTX-CF), bleomycin-cyclophosphamide-dactinomycin (BCD), ifosfamide (IFO) and cyclophosphamide (CTX), etc., and the distance-disease-free survival is 42–89% [1–3].