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Carbon Nanotubes in Cancer Therapy
Published in Yasser Shahzad, Syed A.A. Rizvi, Abid Mehmood Yousaf, Talib Hussain, Drug Delivery Using Nanomaterials, 2022
Renu Sankar, V.K. Ameena Shirin, Chinnu Sabu, K. Pramod
Cancer vaccine consists of antigens that are derived from tumor cells, which will provoke our immune responses (Parish 2003). The anticancer immune responses generated by the cancer vaccine target all tumor cells present in the body and hence these vaccines can be given to metastatic tumors also (Schlom, Arlen, and Gulley 2007). Further, these vaccines will produce a persistent T cell memory against the cancerous cells thereby provides prolonged protection and patient survival (Pagès et al. 2005). The three important components of cancer vaccine are the antigen, the adjuvant, and the delivery vehicle. The success of the cancer vaccine depends on the proper combination of the above three components (Hassan et al. 2019).
Applications of Antiviral Nanoparticles in Cancer Therapy
Published in Devarajan Thangadurai, Saher Islam, Charles Oluwaseun Adetunji, Viral and Antiviral Nanomaterials, 2022
Anusha Konatala, Sai Brahma Penugonda, Fain Parackel, Sudhakar Pola
Cancer immunotherapy has exploded in the past few decades. However, standalone cancer therapy or combination therapy have shown minimal efficacy. Unlike preventative vaccines, cancer vaccines affect cancer-causing cells by helping immune cells recognise tumour associated antigens present on cancer cells. Nanomaterials emulate cellular components in their biophysical and biochemical properties (Yang et al. 2016).
Human serum albumin depletion based on dye ligand affinity chromatography via magnetic microcryogels
Published in Journal of Biomaterials Science, Polymer Edition, 2023
Merve Asena Özbek, Nilay Bereli, Erdoğan Özgür, Adil Denizli
The use of advanced matrices and three-dimensional scaffolds in bioseparation and removal processes is increasing due to their unique properties. In this regard, macroporous polymeric materials offer robust, efficient, and cost-effective technologies for different applications in various research disciplines [6–8]. Cryogels, one of them, have been reported to have advantages such as flexibility, short diffusion paths, and high mechanical strength compared to other biomaterials [9–12]. From this point of view, micron-sized cryogels called microcryogels have been prepared in recent years. Microcryogels, which are easily prepared and biocompatible materials, attract attention in many different areas such as purification processes, drug and cell delivery, and cancer vaccine applications [13–18].
Long-time behavior of solutions to free boundary problems modeling tumor evolution
Published in Applicable Analysis, 2022
In a very recent work [10], the authors studied the asymptotic behavior of the tumor in two models similar to the system (1)–(5) under various boundary conditions. They include in the models treatment of the cancer with two drugs and they address the question of how the two drugs affect the asymptotic behavior. The first drug is a checkpoint inhibitor which disables checkpoint receptors on the T cells, and thus enables the T cells to remain active and kill cancer cells. The killing rate η, in this paper, plays the same role as a checkpoint inhibitor. The second drug is either the oncolytic virus or cancer vaccine. Combination therapy of cancer with cancer vaccine and checkpoint inhibitor was studied numerically in more comprehensive models [9,11].
How combination therapies shape drug resistance in heterogeneous tumoral populations
Published in Letters in Biomathematics, 2018
E. Piretto, M. Delitala, M. Ferraro
In order to increase the efficiency of the treatments, and motivated by the results obtained in the first part of this work, another treatment, affecting both cancer types, is modelled, namely the p53 cancer vaccine, a standard clinical in the treatment of NSCLC (Antonia et al., 2006).