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Contrast enhancement agents and radiopharmaceuticals
Published in A Stewart Whitley, Jan Dodgeon, Angela Meadows, Jane Cullingworth, Ken Holmes, Marcus Jackson, Graham Hoadley, Randeep Kumar Kulshrestha, Clark’s Procedures in Diagnostic Imaging: A System-Based Approach, 2020
A Stewart Whitley, Jan Dodgeon, Angela Meadows, Jane Cullingworth, Ken Holmes, Marcus Jackson, Graham Hoadley, Randeep Kumar Kulshrestha
In the majority of NSF patients, the earliest lesions appear on the lower extremities, followed by upper extremities and then the trunk. The skin involvement is often symmetrical and bilateral. Many patients experience loss of movement in joints due to skin thickening leading to contractures of the extremities. About 5% of patients have a rapidly progressive disease course resulting in cachexia and even death.
Synthesis, spectroscopic characterization and computational study of Ru(II)/DMSO complexes with monocoordinated carbazate ligands
Published in Journal of Coordination Chemistry, 2020
Luana M. Sousa, Diesley M. S. Araújo, Katia M. Oliveira, Letícia P. De Oliveira, Pedro I. S. Maia, Victor M. Deflon, Alzir A. Batista, Antônio E. H. Machado, Wendell Guerra, Gustavo Von Poelhsitz
Carbazates (R–O–C = O–NH–NH2) are hydrazide derivatives showing monodentate or bidentate coordination modes depending on the metallic center involved. Their biological properties are still few explored but carbazates derived from N-amino-1,2,3,4-tetrahydroisoquinoline and N-aminomorpholine are potent inhibitors of hormone-sensitive lipase (HSL), that is a neutral lipase acting as a catalyst in the hydrolysis of triacylglycerol, diacylglycerol, monoacylglycerol, cholesteryl esters and retinyl esters in the human body [20]. Some cancers, especially pancreatic and breast, are associated with a complex syndrome leading to muscle loss named cachexia [21]. It has been proposed that increased levels of HSL are related to cachexia, in this context, pharmacological inhibitors of HSL have been proposed for the treatment of cancer-associated cachexia [22]. The bioinorganic chemistry of complexes containing carbazates has been explored by some researchers. For example, cis and trans-complexes of Pt(II) and Pd(II), respectively, coordinated to 4-methoxybenzylcarbazate (4-mc), benzyl carbazate (bc), ethyl carbazate (ec) and tert-butylcarbazate (tc) showed in vitro anticancer activity against K562 cell line [23, 24]. Also, Govindarajan and collaborators related a series of octahedral complexes of formula [M(NCS)(L)], in which M = Co(II) and Ni(II), NCS = thiocyanate and L = benzyl 2-(alkan-2-ylidene)carbazate. These complexes showed the ability of binding to CT-DNA through a partial intercalation mode and also strongly binding to HSA [25].