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Tissue Engineering and Application in Tropical Medicine
Published in Rajesh K. Kesharwani, Raj K. Keservani, Anil K. Sharma, Tissue Engineering, 2022
Leprosy is an important Mycobacterium infection. It is common in several poor tropical countries. In severe cases, the neuropathy can be seen. The permanent destroy of nerve becomes the important pathology in leprosy. The problem is noncurable by standard management. The use of tissue engineering might be the new hope for management of leprosy-related neuropathy (Illarramendi et al., 2012). In leprosy, chronic ulcers are a common sequelae and the delayed healing of chronic plantar ulcers due to leprosy is the lack of growth factors and cytokines (Natallya et al., 2019). The tissue engineering is the new hope for management of this problem (Dickinson and Gerecht, 2015). Sivasubramanian et al. (2018) reported using new human amnion (Amn)-derived biomaterial scaffolds in healing chronic wounds in leprosy-cured, but deformed, persons. Natallya et al. (2019) reported using human amniotic membrane stem cell secretome gel for healing of leprosy chronic plantar ulcers. Natallya et al. (2019) noted that this new therapeutic approach was effective.
Controlled Therapeutic Delivery in Wound Healing
Published in Emmanuel Opara, Controlled Drug Delivery Systems, 2020
Adam Jorgensen, Zishuai Chou, Sean Murphy
Amniotic epithelial cells are a highly multipotent epithelial cell population isolated from the amnion. They develop from the epiblast 8 days after fertilization and prior to gastrulation. Due to this timing of development, amnion epithelial cells maintain the plasticity of pregastrulation embryonic cells [129].
Effect of umbilical cord length on early fetal biomechanics
Published in Computer Methods in Biomechanics and Biomedical Engineering, 2021
Juan Felipe Sánchez Gutiérrez, Mercedes Olaya-C, Jorge Andrés Franco, Johana Guevara, Diego Alexander Garzón-Alvarado, María Lucía Gutiérrez Gómez
Even earlier, in gestation, another important structure, the amniotic sac, appears at the beginning of the second week from a layer of cells expanding into a thin membrane, the amnion. This structure is completely established by eight weeks of gestation (Schoenwolf et al. 2014). Moreover, fluid known as the amniotic fluid (AF) begins to collect within the sac (Schoenwolf et al. 2014). This fluid functions to facilitate molecule transport between the mother and the developing embryo/fetus (Underwood et al. 2005). Additionally, the AF is a protective liquid that serves as a mechanical buffer, allowing fetal movement and growth. The AF and the UC are important structures that participate in the correct embryo and fetal development and movement.
Disinfection of Human Amniotic Membrane Using a Hydrodynamic System with Ozonated Water
Published in Ozone: Science & Engineering, 2023
Sílvia Móbille Awoyama, Henrique Cunha Carvalho, Túlia de Souza Botelho, Sandra Irene Sprogis Dos Santos, Debora Alicia Buendia Palacios, Sebastian San Martín Henríque, Renato Amaro Zângaro, Carlos José de Lima, Adriana Barrinha Fernandes
Human amniotic membrane (hAM), or amnion, is the thin membrane in the innermost layer of the placenta that surrounds the developing fetus and forms the amniotic cavity, which is filled with amniotic fluid (Mamede et al. 2012; Pollard, Aye, Symonds, 1976; Herendeael, Oberti, Brosens, 1978). The hAM is composed of a monolayer of cuboidal epithelial cells, similar to epidermal cells, which are attached to a thick basement membrane and an avascular stromal matrix composed of dispersed fibroblasts in a collagen structure. Collagen types I, III, IV, V and VII, laminin, and fibronectin have been identified in the basement membrane and stroma of hAM. Laminin and fibronectin are especially effective in facilitating cell adhesion (EDQM, 2017).