China
Africa
Explore chapters and articles related to this topic
Combined Exposure
Published in Fina P. Kaloyanova, Mostafa A. El Batawi, Human Toxicology of Pesticides, 2019
Fina P. Kaloyanova, Mostafa A. El Batawi
Allergic diseases in agricultural workers are often related to pesticides.29,30 Vasher and Vallet published a study on the frequency and etiology of allergies supposedly caused by pesticides and fertilizers used in France for 10 years.31 Out of a total of 9864 allergies, 690 (14%) could be attributed to pesticides and fertilizers. According to the clinical picture, the authors arranged them in the following order: Allergies with predominating skin manifestations, 511 cases including 412 cases of contact dermatitis and 89 cases of atopic and other dermatitis (urticaria and angioneurotic edema of Quincke, simple erythema nodosum, pigment erythema, nonthrombopenic purpura, and erythrodermia)Respiratory allergy, 117 cases (including asthma in 17% of the cases)Blood manifestations, 15 cases, e.g. isolated eosinophilia, hemolytic anemia, leukopenia, agranulocytosis, and thrombopenic purpuraSerum disease, 8 casesAnaphylactic shock (as an exception), 4 casesOtorhinolaryngologic disturbances, 28 cases (rhinitis, sinuitis, laryngitis, otitis)
Life-Threatening and Fatal Therapeutic Misadventures
Published in Marilyn Sue Bogner, Human Error in Medicine, 2018
On the other hand, deaths resulting from complications and/or developments of the injury or disease for which the patient sought the initial care and inherent side effects or natural complications of the diagnostic or therapeutic procedure should not be considered as therapeutic misadventures. Examples of such adverse nonaccidental events include cardiac arrests occurring during a monitored stress exercise, pneumonia developing after a surgical procedure, or agranulocytosis following treatment with chemotherapeutic agents. In contrast, therapeutic misadventures have clear accidental connotations and are subject to a medico-legal investigation.
Assessment of the cytoprotective effect of the homeopathic compound Canova® on African green monkey kidney (VERO) cell line exposed to the drug dipyrone sodium
Published in Journal of Toxicology and Environmental Health, Part A, 2021
Laís Teixeira Bonfim, Tatiane Cristina Mota, Jéssica Juliana Gomes, Emerson da Silva, Lorena Monteiro Gomes, Rommel Mario Rodríguez Burbano, Marcelo Oliveira Bahia
Dipyrone (DIP) or metamizole is a non-opioid prodrug used as analgesic in many countries (De Leeuw et al. 2017; Reist et al. 2018). An increasing worldwide commercialization of DIP or metamizole occurred until the 70s, when serious cases of agranulocytosis related to its use were reported (Andrade et al. 2016). Although the incidence of this effect shows huge variation and remains uncertain (Kötter et al. 2015; Vuik et al. 2017), most of the Northern Hemisphere has banned the prescription of DIP (Dall’Olio et al. 2003). However, this drug continues to be used in countries such as Austria, Belgium, Italy, the Netherlands, Turkey, Spain, Russia, South Africa and also in Latin America due to its low cost and proven efficacy (Rogosch et al. 2012). In addition to agranulocytosis, some investigators noted rare, albeit important, cases of acute kidney injury (AKI) in patients under treatment with the drug (Hassan et al. 2011; Redondo-Pachon et al. 2014). Stueber et al. (2017) in a retrospective study demonstrated that AKI is associated with DIP treatment in a dose-dependent manner.